Monthly Archives: December 2015

Is Proton Pump Inhibitor Use Associated With Risk of Myocardial Infarction?

Shah NH, LePendu P, Bauer-Mehren A, et al. Proton pump inhibitor usage and the risk of myocardial infarction in the general population. PLoS One 2015;10:e0124653. Continue reading

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Minimal Transplant Survival Benefit for Hepatocellular Carcinoma: Is it Real or an Overestimation of Waitlist Life Expectancy?

We read with interest the article by Berry and Ioannou1 examining the net transplant survival benefit in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) when compared to those without HCC based on analysis of the UNOS … Continue reading

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Minimal Transplant Survival Benefit for Hepatocellular Carcinoma: Is it Real or an Overestimation of Waitlist Life Expectancy?

We read with interest the article by Berry and Ioannou1 examining the net transplant survival benefit in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) when compared to those without HCC based on analysis of the UNOS … Continue reading

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A Rare Pancreatic Tumor That Underwent a Change in Morphology and Histopathologic Features During Chemotherapy

Question: A 63-year-old man visited our hospital because of epigastric discomfort. He had no family history of pancreatic cancer, and abdominal examination was unremarkable. Serum levels of elastase 1 (1199 ng/dL; normal 100–400) and DUPAN2 (190 U/mL; normal <150) were elevated; however, serum levels of carcinoembryonic antigen, carbohydrate antigen 19-9, pancreatic polypeptide, gastrin, insulin, and vasoactive intestinal peptide were normal. Abdominal computed tomography (CT) showed a well-marginated round mass, 6 cm in diameter, in the pancreatic head, as well as a dilated caudal main pancreatic duct. Continue reading

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A Rare Pancreatic Tumor That Underwent a Change in Morphology and Histopathologic Features During Chemotherapy

Question: A 63-year-old man visited our hospital because of epigastric discomfort. He had no family history of pancreatic cancer, and abdominal examination was unremarkable. Serum levels of elastase 1 (1199 ng/dL; normal 100–400) and DUPAN2 (190 U/mL; normal <150) were elevated; however, serum levels of carcinoembryonic antigen, carbohydrate antigen 19-9, pancreatic polypeptide, gastrin, insulin, and vasoactive intestinal peptide were normal. Abdominal computed tomography (CT) showed a well-marginated round mass, 6 cm in diameter, in the pancreatic head, as well as a dilated caudal main pancreatic duct. Continue reading

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Effect of Amitriptyline and Escitalopram on Functional Dyspepsia

In the conclusion to their randomized, double-blind, placebo-controlled trial investigating the effect of amitriptyline and escitalopram in functional dyspepsia (FD), Talley et al 1 report that “amitriptyline appeared beneficial in FD”. In the edi… Continue reading

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An Unusual Cause of Obscure Gastrointestinal Bleeding

Question: An 88-year-old woman presented to our hospital with episodic melena, fatigue, and shortness of breath for 6 months. Her medical history was significant for hypertension, for which she had been prescribed enteric-coated aspirin and amlodipine… Continue reading

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An Unusual Cause of Obscure Gastrointestinal Bleeding

Question: An 88-year-old woman presented to our hospital with episodic melena, fatigue, and shortness of breath for 6 months. Her medical history was significant for hypertension, for which she had been prescribed enteric-coated aspirin and amlodipine… Continue reading

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An Unusual Cause of Chronic Diarrhea

A 41-year-old female patient with medical history of bipolar disorder, on topiramate and quetiapine for several years and on sertraline for the last 4 months, presented to the emergency department with diarrhea (6–8 bowel movements per day, watery st… Continue reading

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An Unusual Cause of Chronic Diarrhea

A 41-year-old female patient with medical history of bipolar disorder, on topiramate and quetiapine for several years and on sertraline for the last 4 months, presented to the emergency department with diarrhea (6–8 bowel movements per day, watery st… Continue reading

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