Daily Archives: January 2, 2016

Expanding the boundaries of endoscopic resection – Circumferential laterally spreading lesions of the duodenum

Posted on January 2, 2016 by Amir Klein, Nicholas Tutticci, Rajvinder Singh, Michael J. Bourke
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Histamine Receptor H1-mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

Posted on January 2, 2016 by Mira M. Wouters, Dafne Balemans, Sander Van Wanrooy, James Dooley, Vincent Cibert-Goton, Yeranddy A. Alpizar, Eduardo E. Valdez-Morales, Yasmin Nasser, Paul P. Van Veldhoven, Winde Vanbrabant, Schalk Van der Merwe, Raf Mols, Bart Ghesquière, Carla Ci

Histamine sensitizes the nociceptor TRPV1 and has been shown to contribute to visceral hypersensitivity in animals. We investigated the role of TRPV1 in irritable bowel syndrome (IBS) and evaluated if an antagonist of histamine receptor H1 (HRH1) could… Continue reading →

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Histamine Receptor H1-mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

Posted on January 2, 2016 by Mira M. Wouters, Dafne Balemans, Sander Van Wanrooy, James Dooley, Vincent Cibert-Goton, Yeranddy A. Alpizar, Eduardo E. Valdez-Morales, Yasmin Nasser, Paul P. Van Veldhoven, Winde Vanbrabant, Schalk Van der Merwe, Raf Mols, Bart Ghesquière, Carla Ci

Histamine sensitizes the nociceptor TRPV1 and has been shown to contribute to visceral hypersensitivity in animals. We investigated the role of TRPV1 in irritable bowel syndrome (IBS) and evaluated if an antagonist of histamine receptor H1 (HRH1) could… Continue reading →

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Variable Extent of Intra-tumor Heterogeneity Revealed by Genomic Sequencing of Multiple Lesions in Patients with Hepatocellular Carcinoma

Posted on January 2, 2016 by Ruidong Xue, Ruoyan Li, Hua Guo, Lin Guo, Zhe Su, Xiaohui Ni, Lisha Qi, Ti Zhang, Qiang Li, Zemin Zhang, Xiaoliang Sunney Xie, Fan Bai, Ning Zhang

Many patients with hepatocellular carcinoma (HCC) have multiple lesions (primary tumors, intrahepatic metastases, multiple occurrences, satellite nodules, and tumor thrombi); these have been associated with a poor prognosis and tumor recurrence after s… Continue reading →

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Variable Extent of Intra-tumor Heterogeneity Revealed by Genomic Sequencing of Multiple Lesions in Patients with Hepatocellular Carcinoma

Posted on January 2, 2016 by Ruidong Xue, Ruoyan Li, Hua Guo, Lin Guo, Zhe Su, Xiaohui Ni, Lisha Qi, Ti Zhang, Qiang Li, Zemin Zhang, Xiaoliang Sunney Xie, Fan Bai, Ning Zhang

Many patients with hepatocellular carcinoma (HCC) have multiple lesions (primary tumors, intrahepatic metastases, multiple occurrences, satellite nodules, and tumor thrombi); these have been associated with a poor prognosis and tumor recurrence after s… Continue reading →

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Microsatellite Alterations with Allelic Loss at 9p24.2 Signify Less-aggressive Colorectal Cancer Metastasis

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Molecular events that lead to recurrence and/or metastasis after curative treatment of patients with colorectal cancers (CRCs) are poorly understood. Patients with stage II or III primary CRC with increased numbers of microsatellite alterations at sele… Continue reading →

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Expanding the Boundaries of Endoscopic Resection: Circumferential Laterally Spreading Lesions of the Duodenum

Posted on January 2, 2016 by Amir Klein, Nicholas Tutticci, Rajvinder Singh, Michael J. Bourke

Lateral spreading lesions (LSL) of the duodenum are uncommon. They may or may not involve the papilla Vatteri and are usually solitary flat adenomas that harbor a malignant potential similar to colonic adenomas and removal is therefore recommended.1,2 … Continue reading →

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Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis

Posted on January 2, 2016 by

Molecular events that lead to recurrence and/or metastasis after curative treatment of patients with colorectal cancers (CRCs) are poorly understood. Patients with stage II or III primary CRC with elevated microsatellite alterations at selected tetranu… Continue reading →

Posted in News | Comments Off on Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis