Since its initial description in the early 1990s, eosinophilic esophagitis (EoE) was considered a clinicopathologic syndrome, for which the diagnostic hallmark consisted of esophageal symptoms coupled with high concentrations of intraepithelial eosinophils in esophageal biopsies. Over the past few years, we have gained significant knowledge on EoE, including its epidemiology,1 full clinical spectrum, classification of endoscopic findings,2 characterization of abnormal esophageal motility patterns,3 the potential pathogenic role of acid exposure,4 insight on its genetic signature,5 and the efficacy of several therapeutic options, including dietary modifications,6 proton pump inhibitors,7 topical steroids,8 and endoscopic esophageal dilation.