Monthly Archives: January 2016

A family history of colorectal cancer (CRC) in a first-degree relative increases one’s average lifetime risk of CRC.1–3 The magnitude of the risk increase is affected by the age of the individual, age of the affected relative, number of affected re… Continue reading →

Since its initial description in the early 1990s, eosinophilic esophagitis (EoE) was considered a clinicopathologic syndrome, for which the diagnostic hallmark consisted of esophageal symptoms coupled with high concentrations of intraepithelial eosinop… Continue reading →

Since its initial description in the early 1990s, eosinophilic esophagitis (EoE) was considered a clinicopathologic syndrome, for which the diagnostic hallmark consisted of esophageal symptoms coupled with high concentrations of intraepithelial eosinop… Continue reading →

The rs58542926 C>T variant of the transmembrane 6 superfamily member 2 gene (TM6SF2), encoding an E167K amino acid substitution, has been correlated with reduced total cholesterol (TC) and cardiovascular disease. However, little is known about the role of TM6SF2 in metabolism. We investigated the long-term effects of altered TM6SF2 levels in cholesterol metabolism. Continue reading →

The rs58542926 C>T variant of the transmembrane 6 superfamily member 2 gene (TM6SF2), encoding an E167K amino acid substitution, has been correlated with reduced total cholesterol (TC) and cardiovascular disease. However, little is known about the role of TM6SF2 in metabolism. We investigated the long-term effects of altered TM6SF2 levels in cholesterol metabolism. Continue reading →

The combination of β-blockers and band ligation is the standard approach to prevent variceal rebleeding, but bleeding recurs and mortality is high. The lipid-lowering drug simvastatin decreases portal pressure, improves hepatocellular function, and mi… Continue reading →

The combination of β-blockers and band ligation is the standard approach to prevent variceal rebleeding, but bleeding recurs and mortality is high. The lipid-lowering drug simvastatin decreases portal pressure, improves hepatocellular function, and mi… Continue reading →

We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often… Continue reading →