Monthly Archives: February 2016
Genetic Factors That Affect Risk of Alcoholic and Non-Alcoholic Fatty Liver Disease
Genome-wide association studies (GWAS) and candidate gene studies have informed our understanding of factors contributing to the well-recognized inter-individual variation in progression and outcomes of alcoholic liver disease (ALD) and non-alcoholic f… Continue reading
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Genetic Factors That Affect Risk of Alcoholic and Non-Alcoholic Fatty Liver Disease
Genome-wide association studies (GWAS) and candidate gene studies have informed our understanding of factors contributing to the well-recognized inter-individual variation in progression and outcomes of alcoholic liver disease (ALD) and non-alcoholic f… Continue reading
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Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population
Esophageal squamous cell carcinoma (ESCC) is the predominant form of esophageal cancer in Japan. Smoking and drinking are environmental risk factors for ESCC, whereas single nucleotide polymorphisms in ADH1B and ALDH2, which increase harmful intermedia… Continue reading
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Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population
Esophageal squamous cell carcinoma (ESCC) is the predominant form of esophageal cancer in Japan. Smoking and drinking are environmental risk factors for ESCC, whereas single nucleotide polymorphisms in ADH1B and ALDH2, which increase harmful intermedia… Continue reading
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C-type Lectin-like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of PI3K Subunits
C-type lectin-like receptor 2 (CLEC2) is a transmembrane receptor expressed on platelets and several hematopoietic cells. CLEC2 regulates platelet aggregation and the immune response. We investigated its expression and function in normal and transforme… Continue reading
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C-type Lectin-like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of PI3K Subunits
C-type lectin-like receptor 2 (CLEC2) is a transmembrane receptor expressed on platelets and several hematopoietic cells. CLEC2 regulates platelet aggregation and the immune response. We investigated its expression and function in normal and transforme… Continue reading
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Post-Polypectomy Surveillance: Looking for the Goldilocks “Just Right” Zone
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Post-Polypectomy Surveillance: Looking for the Goldilocks “Just Right” Zone
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The Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7–TMC4 is a susceptibility locus for the development and progression of NAFLD. Continue reading
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The Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7–TMC4 is a susceptibility locus for the development and progression of NAFLD. Continue reading
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