Monthly Archives: March 2016

Cancer Recurrence Following Immune-Suppressive Therapies in Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis

Posted on March 31, 2016 by Edward Shelton, David Laharie, Frank I. Scott, Ronac Mamtani, James D. Lewis, Jean-Frederic Colombel, Ashwin N. Ananthakrishnan

Physicians frequently encounter patients with immune-mediated diseases and a history of malignancy. There are limited data on the safety of immunosuppressive therapy for these patients. Published studies have been small with few events, precluding rob… Continue reading →

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Cancer Recurrence Following Immune-Suppressive Therapies in Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis

Posted on March 31, 2016 by Edward Shelton, David Laharie, Frank I. Scott, Ronac Mamtani, James D. Lewis, Jean-Frederic Colombel, Ashwin N. Ananthakrishnan

Physicians frequently encounter patients with immune-mediated diseases and a history of malignancy. There are limited data on the safety of immunosuppressive therapy for these patients. Published studies have been small with few events, precluding rob… Continue reading →

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Effects of Eradicating Hepatitis C Virus Infection in Patients With Cirrhosis Differ With Stage of Portal Hypertension

Posted on March 31, 2016 by Vito Di Marco, Vincenza Calvaruso, Donatella Ferraro, Maria Grazia Bavetta, Giuseppe Cabibbo, Elisabetta Conte, Calogero Cammà, Stefania Grimaudo, Rosaria Maria Pipitone, Fabio Simone, Sergio Peralta, Andrea Arini, Antonio Craxì

Clearance of hepatitis C virus (HCV) via antiviral treatment changes the course of liver disease. We evaluated the benefit of sustained virologic response (SVR) in patients with HCV and cirrhosis without (stage 1) and with (stage 2) esophageal varices … Continue reading →

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Effects of Eradicating Hepatitis C Virus Infection in Patients With Cirrhosis Differ With Stage of Portal Hypertension

Posted on March 31, 2016 by Vito Di Marco, Vincenza Calvaruso, Donatella Ferraro, Maria Grazia Bavetta, Giuseppe Cabibbo, Elisabetta Conte, Calogero Cammà, Stefania Grimaudo, Rosaria Maria Pipitone, Fabio Simone, Sergio Peralta, Andrea Arini, Antonio Craxì

Clearance of hepatitis C virus (HCV) via antiviral treatment changes the course of liver disease. We evaluated the benefit of sustained virologic response (SVR) in patients with HCV and cirrhosis without (stage 1) and with (stage 2) esophageal varices … Continue reading →

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Administration of Antibiotics to Children Before Age 2 Years Increases Risk for Childhood Obesity

Posted on March 19, 2016 by Frank I. Scott, Daniel B. Horton, Ronac Mamtani, Kevin Haynes, David S. Goldberg, Dale Y. Lee, James D. Lewis

Childhood obesity is increasing and is associated with adult obesity. Antibiotics have been used to promote weight gain in livestock for several decades. Antibiotics are commonly prescribed for children, but it is not clear how exposure to antibiotics … Continue reading →

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Administration of Antibiotics to Children Before Age 2 Years Increases Risk for Childhood Obesity

Posted on March 19, 2016 by Frank I. Scott, Daniel B. Horton, Ronac Mamtani, Kevin Haynes, David S. Goldberg, Dale Y. Lee, James D. Lewis

Childhood obesity is increasing and is associated with adult obesity. Antibiotics have been used to promote weight gain in livestock for several decades. Antibiotics are commonly prescribed for children, but it is not clear how exposure to antibiotics … Continue reading →

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Polyclonal Crypt Genesis and Development of Familial Small Intestinal Neuroendocrine Tumors

Posted on March 19, 2016 by Yoshitatsu Sei, Jianying Feng, Xilin Zhao, Joanne Forbes, Derek Tang, Kunio Nagashima, Jeffrey Hanson, Martha M. Quezado, Marybeth S. Hughes, Stephen A. Wank

Small intestinal neuroendocrine tumors (SI-NETs) are serotonin-secreting well-differentiated neuroendocrine tumors believed to originate from enterochromaffin (EC) cells. Intestinal stem cell (ISC) are believed to contribute to the formation of SI-NETs… Continue reading →

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Polyclonal Crypt Genesis and Development of Familial Small Intestinal Neuroendocrine Tumors

Posted on March 19, 2016 by Yoshitatsu Sei, Jianying Feng, Xilin Zhao, Joanne Forbes, Derek Tang, Kunio Nagashima, Jeffrey Hanson, Martha M. Quezado, Marybeth S. Hughes, Stephen A. Wank

Small intestinal neuroendocrine tumors (SI-NETs) are serotonin-secreting well-differentiated neuroendocrine tumors believed to originate from enterochromaffin (EC) cells. Intestinal stem cell (ISC) are believed to contribute to the formation of SI-NETs… Continue reading →

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Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

Posted on March 19, 2016 by Sonja M. Wörmann, Liang Song, Jiaoyu Ai, Kalliope N. Diakopoulos, Magdalena U. Kurkowski, Kivanc Görgülü, Dietrich Ruess, Andrew Campbell, Claudio Doglioni, Duncan Jodrell, Albrecht Neesse, Ihsan E. Demir, Angelica-Phaedra Karpathaki, Maxim Barenboim

One treatment strategy for pancreatic ductal adenocarcinoma is to modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) is associated with progression of pancreatic and … Continue reading →

Posted in News | Comments Off on Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

Posted on March 19, 2016 by Sonja M. Wörmann, Liang Song, Jiaoyu Ai, Kalliope N. Diakopoulos, Magdalena U. Kurkowski, Kivanc Görgülü, Dietrich Ruess, Andrew Campbell, Claudio Doglioni, Duncan Jodrell, Albrecht Neesse, Ihsan E. Demir, Angelica-Phaedra Karpathaki, Maxim Barenboim

One treatment strategy for pancreatic ductal adenocarcinoma is to modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) is associated with progression of pancreatic and … Continue reading →

Posted in News | Comments Off on Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival