Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells

Posted on March 10, 2016 by Katharina Timper, Elise Dalmas, Erez Dror, Sabine Rütti, Constanze Thienel, Nadine S. Sauter, Karim Bouzakri, Benoit Bédat, Francois Pattou, Julie Kerr-Conte, Marianne Böni-Schnetzler, Marc Y. Donath

Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and α cells, leading to secretion of insulin from β cells. We investigated whether GIP regulates GLP1 and glycemia via IL6.

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