Monthly Archives: April 2016

Getting Into the Weed: The Role of the Endocannabinoid System in the Brain–Gut Axis

Posted on April 28, 2016 by Keith A. Sharkey, John W. Wiley

The actions of cannabis are mediated by receptors that are part of an endogenous cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring ligands N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG),… Continue reading →

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Getting Into the Weed: The Role of the Endocannabinoid System in the Brain–Gut Axis

Posted on April 28, 2016 by Keith A. Sharkey, John W. Wiley

The actions of cannabis are mediated by receptors that are part of an endogenous cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring ligands N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG),… Continue reading →

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Mouse and Human Liver Contain Immunoglobulin A–Secreting Cells Originating From Peyer’s Patches and Directed Against Intestinal Antigens

Posted on April 28, 2016 by Ludovic Moro-Sibilot, Pascal Blanc, Morgan Taillardet, Emilie Bardel, Coline Couillault, Gilles Boschetti, Alexandra Traverse-Glehen, Thierry Defrance, Dominique Kaiserlian, Bertrand Dubois

The liver receives blood from the gastrointestinal tract through the portal vein, and thereby is exposed continuously to dietary antigens and commensal bacteria. Alcoholic liver disease (ALD) is associated with intestinal dysbiosis, increased intestina… Continue reading →

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Mouse and Human Liver Contain Immunoglobulin A–Secreting Cells Originating From Peyer’s Patches and Directed Against Intestinal Antigens

Posted on April 28, 2016 by Ludovic Moro-Sibilot, Pascal Blanc, Morgan Taillardet, Emilie Bardel, Coline Couillault, Gilles Boschetti, Alexandra Traverse-Glehen, Thierry Defrance, Dominique Kaiserlian, Bertrand Dubois

The liver receives blood from the gastrointestinal tract through the portal vein, and thereby is exposed continuously to dietary antigens and commensal bacteria. Alcoholic liver disease (ALD) is associated with intestinal dysbiosis, increased intestina… Continue reading →

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Risks of Bleeding Recurrence and Cardiovascular Events With Continued Aspirin Use After Lower Gastrointestinal Hemorrhage

Posted on April 26, 2016 by Francis K.L. Chan, En-Ling Leung Ki, Grace L.H. Wong, Jessica Y.L. Ching, Yee Kit Tse, Kim W.L. Au, Justin C.Y. Wu, Siew C. Ng

It is not clear whether use of low-dose aspirin should be resumed after an episode of lower gastrointestinal (GI) bleeding. We assessed the long-term risks of recurrent lower GI bleeding and serious cardiovascular outcomes after aspirin-associated lowe… Continue reading →

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Risks of Bleeding Recurrence and Cardiovascular Events With Continued Aspirin Use After Lower Gastrointestinal Hemorrhage

Posted on April 26, 2016 by Francis K.L. Chan, En-Ling Leung Ki, Grace L.H. Wong, Jessica Y.L. Ching, Yee Kit Tse, Kim W.L. Au, Justin C.Y. Wu, Siew C. Ng

It is not clear whether use of low-dose aspirin should be resumed after an episode of lower gastrointestinal (GI) bleeding. We assessed the long-term risks of recurrent lower GI bleeding and serious cardiovascular outcomes after aspirin-associated lowe… Continue reading →

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The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults

Posted on April 18, 2016 by Carlo A. Fallone, Naoki Chiba, Sander Veldhuyzen van Zanten, Lori Fischbach, Javier P. Gisbert, Richard H. Hunt, Nicola L. Jones, Craig Render, Grigorios I. Leontiadis, Paul Moayyedi, John K. Marshall

Helicobacter pylori infection is increasingly difficult to treat. The purpose of these consensus statements is to provide a review of the literature and specific, updated recommendations for eradication therapy in adults. Continue reading →

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The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults

Posted on April 18, 2016 by Carlo A. Fallone, Naoki Chiba, Sander Veldhuyzen van Zanten, Lori Fischbach, Javier P. Gisbert, Richard H. Hunt, Nicola L. Jones, Craig Render, Grigorios I. Leontiadis, Paul Moayyedi, John K. Marshall

Helicobacter pylori infection is increasingly difficult to treat. The purpose of these consensus statements is to provide a review of the literature and specific, updated recommendations for eradication therapy in adults. Continue reading →

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Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies

Posted on April 16, 2016 by Amit D. Joshi, Charlotte Andersson, Stephan Buch, Stefan Stender, Raymond Noordam, Lu-Chen Weng, Peter E. Weeke, Paul L. Auer, Bernhard Boehm, Constance Chen, Hyon Choi, Gary Curhan, Joshua C. Denny, Immaculata De Vivo, John D. Eicher, David Ellingha

A genome-wide association study (GWAS) of 280 cases identified the hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease, but findings have not been reported from any other GWAS of this phenotype. We performed a la… Continue reading →

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Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies

Posted on April 16, 2016 by Amit D. Joshi, Charlotte Andersson, Stephan Buch, Stefan Stender, Raymond Noordam, Lu-Chen Weng, Peter E. Weeke, Paul L. Auer, Bernhard Boehm, Constance Chen, Hyon Choi, Gary Curhan, Joshua C. Denny, Immaculata De Vivo, John D. Eicher, David Ellingha

A genome-wide association study (GWAS) of 280 cases identified the hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease, but findings have not been reported from any other GWAS of this phenotype. We performed a la… Continue reading →

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