Monthly Archives: April 2016

An Unusual Cause of Massive Ascites

Posted on April 13, 2016 by Uichiro Fuchizaki, Kazutoshi Yamada, Shogo Matsuda

Question: A 78-year-old man was admitted because of an exacerbation of interstitial pneumonia and was started on steroid therapy. On the next hospital day, he had a stroke. Because of persistent dysphagia, a percutaneous endoscopic gastrostomy tube was… Continue reading →

Posted in News | Comments Off on An Unusual Cause of Massive Ascites

An Unusual Cause of Massive Ascites

Posted on April 13, 2016 by Uichiro Fuchizaki, Kazutoshi Yamada, Shogo Matsuda

Question: A 78-year-old man was admitted because of an exacerbation of interstitial pneumonia and was started on steroid therapy. On the next hospital day, he had a stroke. Because of persistent dysphagia, a percutaneous endoscopic gastrostomy tube was… Continue reading →

Posted in News | Comments Off on An Unusual Cause of Massive Ascites

Hepatitis C Virus Resistance to Direct-Acting Antiviral Drugs in Interferon-Free Regimens

Posted on April 11, 2016 by Jean-Michel Pawlotsky

Treatment of hepatitis C virus (HCV) infection has progressed considerably with the approval of interferon-free, direct-acting antiviral (DAA)-based combination therapies. Although most treated patients achieve virological cure, HCV resistance to DAAs … Continue reading →

Posted in News | Comments Off on Hepatitis C Virus Resistance to Direct-Acting Antiviral Drugs in Interferon-Free Regimens

Hepatitis C Virus Resistance to Direct-Acting Antiviral Drugs in Interferon-Free Regimens

Posted on April 11, 2016 by Jean-Michel Pawlotsky

Treatment of hepatitis C virus (HCV) infection has progressed considerably with the approval of interferon-free, direct-acting antiviral (DAA)-based combination therapies. Although most treated patients achieve virological cure, HCV resistance to DAAs … Continue reading →

Posted in News | Comments Off on Hepatitis C Virus Resistance to Direct-Acting Antiviral Drugs in Interferon-Free Regimens

Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

Posted on April 7, 2016 by Rona Yaeger, Manish A. Shah, Vincent A. Miller, Judith R. Kelsen, Kai Wang, Zachary J. Heins, Jeffrey S. Ross, Yuting He, Eric Sanford, Rhonda K. Yantiss, Sohail Balasubramanian, Philip J. Stephens, Nikolaus Schultz, Moshe Oren, Laura Tang, David Kel

Patients with inflammatory bowel diseases, such as Crohn’s disease (CD) and ulcerative colitis (UC), are at increased risk for small bowel or colorectal cancers (colitis-associated cancers [CACs]). We compared the spectrum of genomic alterations in C… Continue reading →

Posted in News | Comments Off on Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

Posted on April 7, 2016 by Rona Yaeger, Manish A. Shah, Vincent A. Miller, Judith R. Kelsen, Kai Wang, Zachary J. Heins, Jeffrey S. Ross, Yuting He, Eric Sanford, Rhonda K. Yantiss, Sohail Balasubramanian, Philip J. Stephens, Nikolaus Schultz, Moshe Oren, Laura Tang, David Kel

Patients with inflammatory bowel diseases, such as Crohn’s disease (CD) and ulcerative colitis (UC), are at increased risk for small bowel or colorectal cancers (colitis-associated cancers [CACs]). We compared the spectrum of genomic alterations in C… Continue reading →

Posted in News | Comments Off on Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection

Posted on April 7, 2016 by Mette Julsgaard, Lisbet A. Christensen, Peter R. Gibson, Richard B. Gearry, Jan Fallingborg, Christian L. Hvas, Bo M. Bibby, Niels Uldbjerg, William R. Connell, Ourania Rosella, Anne Grosen, Steven J. Brown, Jens Kjeldsen, Signe Wildt, Lise Svennings

Little is known about in utero exposure to and postnatal clearance of anti–tumor necrosis factor (anti-TNF) agents in neonates. We investigated the concentrations of adalimumab and infliximab in umbilical cord blood of newborns and rates of clearance… Continue reading →

Posted in News | Comments Off on Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection

Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection

Posted on April 7, 2016 by Mette Julsgaard, Lisbet A. Christensen, Peter R. Gibson, Richard B. Gearry, Jan Fallingborg, Christian L. Hvas, Bo M. Bibby, Niels Uldbjerg, William R. Connell, Ourania Rosella, Anne Grosen, Steven J. Brown, Jens Kjeldsen, Signe Wildt, Lise Svennings

Little is known about in utero exposure to and postnatal clearance of anti–tumor necrosis factor (anti-TNF) agents in neonates. We investigated the concentrations of adalimumab and infliximab in umbilical cord blood of newborns and rates of clearance… Continue reading →

Posted in News | Comments Off on Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection

Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice

Posted on April 5, 2016 by Kirk Bergstrom, Xiaowei Liu, Yiming Zhao, Nan Gao, Qian Wu, Kai Song, Yi Cui, Yun Li, J. Michael McDaniel, Samuel McGee, Weichang Chen, Mark M. Huycke, Courtney W. Houchen, Lauren A. Zenewicz, Christopher M. West, Hong Chen, Jonathan Braun, Jianxin F

Core 1– and core 3–derived mucin-type O-linked oligosaccharides (O-glycans) are major components of the colonic mucus layer. Defective forms of colonic O-glycans, such as the Thomsen-nouveau (Tn) antigen, frequently are observed in patients with ul… Continue reading →

Posted in News | Comments Off on Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice

Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice

Posted on April 5, 2016 by Kirk Bergstrom, Xiaowei Liu, Yiming Zhao, Nan Gao, Qian Wu, Kai Song, Yi Cui, Yun Li, J. Michael McDaniel, Samuel McGee, Weichang Chen, Mark M. Huycke, Courtney W. Houchen, Lauren A. Zenewicz, Christopher M. West, Hong Chen, Jonathan Braun, Jianxin F

Core 1– and core 3–derived mucin-type O-linked oligosaccharides (O-glycans) are major components of the colonic mucus layer. Defective forms of colonic O-glycans, such as the Thomsen-nouveau (Tn) antigen, frequently are observed in patients with ul… Continue reading →

Posted in News | Comments Off on Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice