Daily Archives: May 28, 2016
Integrin αEβ7 in Inflammatory Bowel Disease: Friend or Foe?
We read with great interest the article by Tew et al1 on the association between increased gene expression of integrin αE and granzyme A (GZMA) and clinical remission to etrolizumab treatment in patients with ulcerative colitis (UC). This report foll… Continue reading
Integrin αEβ7 in Inflammatory Bowel Disease: Friend or Foe?
We read with great interest the article by Tew et al1 on the association between increased gene expression of integrin αE and granzyme A (GZMA) and clinical remission to etrolizumab treatment in patients with ulcerative colitis (UC). This report foll… Continue reading
Reply
Thank you for the opportunity to reply to Smids et al regarding our paper in Gastroenterology. Etrolizumab, a humanized monoclonal antibody specific for β7 integrin, blocks both α4β7:MAdCAM-1 as well as αEβ7:E-cadherin interactions. In our phase … Continue reading
Reply
Thank you for the opportunity to reply to Smids et al regarding our paper in Gastroenterology. Etrolizumab, a humanized monoclonal antibody specific for β7 integrin, blocks both α4β7:MAdCAM-1 as well as αEβ7:E-cadherin interactions. In our phase … Continue reading
Roux-en-Y Gastric Bypass and Intestinal Glucose Handling: A Salty Sweet Operation
Gastrointestinal exclusion by Roux-en-Y gastric bypass (RYGB) improves glucose metabolism, beyond weight loss. The underlying mechanisms remain, however, unclear.1 In their recent article,2 Cavin et al studied the changes of intestinal glucose handlin… Continue reading
Roux-en-Y Gastric Bypass and Intestinal Glucose Handling: A Salty Sweet Operation
Gastrointestinal exclusion by Roux-en-Y gastric bypass (RYGB) improves glucose metabolism, beyond weight loss. The underlying mechanisms remain, however, unclear.1 In their recent article,2 Cavin et al studied the changes of intestinal glucose handlin… Continue reading
An Incidentally Discovered Abdominal Mass During Physical Examination
Question: A 66-year-old woman was referred to our hospital for an incidentally discovered abdominal mass during routine physical examination. She had no history of abdominal trauma, liver cirrhosis, or chronic hepatitis virus infection previously, nor … Continue reading
An Incidentally Discovered Abdominal Mass During Physical Examination
Question: A 66-year-old woman was referred to our hospital for an incidentally discovered abdominal mass during routine physical examination. She had no history of abdominal trauma, liver cirrhosis, or chronic hepatitis virus infection previously, nor … Continue reading