Monthly Archives: May 2016
The METEOR Trial: The Burial of Methotrexate in Ulcerative Colitis?
We read with interest the recent work by Carbonnel et al1 reporting the results from the METEOR (Controlled, Randomized, Double-Blind, Multicentre Study Comparing Methotrexate vs Placebo in Steroid Dependant Ulcerative Colitis) trial. We agree with th… Continue reading
The METEOR Trial: The Burial of Methotrexate in Ulcerative Colitis?
We read with interest the recent work by Carbonnel et al1 reporting the results from the METEOR (Controlled, Randomized, Double-Blind, Multicentre Study Comparing Methotrexate vs Placebo in Steroid Dependant Ulcerative Colitis) trial. We agree with th… Continue reading
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We thank Pattou, Daoudi, and Baud for their interest in our work,1 as well as for their complementary work,2 on intestinal absorption of ingested glucose after Roux-en-Y gastric bypass (RYGB). Based on their recent data obtained with a minipig model of… Continue reading
Reply
We thank Pattou, Daoudi, and Baud for their interest in our work,1 as well as for their complementary work,2 on intestinal absorption of ingested glucose after Roux-en-Y gastric bypass (RYGB). Based on their recent data obtained with a minipig model of… Continue reading
A Hazard of Outdoor Grilling
Question: A 63-year-old woman with a 6-year history of fibrostenotic ileocolonic Crohn’s disease (CD) presented for evaluation after multiple hospitalizations for recurrent small bowel obstruction (SBO). Treatment for CD included adalimumab and azath… Continue reading
A Hazard of Outdoor Grilling
Question: A 63-year-old woman with a 6-year history of fibrostenotic ileocolonic Crohn’s disease (CD) presented for evaluation after multiple hospitalizations for recurrent small bowel obstruction (SBO). Treatment for CD included adalimumab and azath… Continue reading
Reply
We thank Macaluso et al for their comments about our study on methotrexate in steroid-dependent ulcerative colitis (UC).1 In this trial, parenteral methotrexate was not superior to placebo, using a composite primary endpoint consisting of clinical and… Continue reading
Reply
We thank Macaluso et al for their comments about our study on methotrexate in steroid-dependent ulcerative colitis (UC).1 In this trial, parenteral methotrexate was not superior to placebo, using a composite primary endpoint consisting of clinical and… Continue reading
Integrin αEβ7 in Inflammatory Bowel Disease: Friend or Foe?
We read with great interest the article by Tew et al1 on the association between increased gene expression of integrin αE and granzyme A (GZMA) and clinical remission to etrolizumab treatment in patients with ulcerative colitis (UC). This report foll… Continue reading
Integrin αEβ7 in Inflammatory Bowel Disease: Friend or Foe?
We read with great interest the article by Tew et al1 on the association between increased gene expression of integrin αE and granzyme A (GZMA) and clinical remission to etrolizumab treatment in patients with ulcerative colitis (UC). This report foll… Continue reading