Gastrointestinal exclusion by Roux-en-Y gastric bypass (RYGB) improves glucose metabolism, beyond weight loss. The underlying mechanisms remain, however, unclear.1 In their recent article,2 Cavin et al studied the changes of intestinal glucose handling induced by this procedure. The authors first showed in rats that RYGB reduces the overall blood glucose response to oral glucose. Second, they measured the RNA expression of glucose transporters (SGLT1 and GLUT1-5) in the various intestinal limbs of RYGB, and estimated intestinal glucose uptake in vitro.