Monthly Archives: June 2016
Prevalence of Resistance-Associated Substitutions in HCV NS5A, NS5B, or NS3 and Outcomes of Treatment with Ledipasvir and Sofosbuvir
We evaluated the effects of baseline hepatitis C virus (HCV) NS5A, NS5B, and NS3 resistance-associated substitutions (RASs) on response to the combination of ledipasvir and sofosbuvir, with or without ribavirin, in patients with HCV genotype 1 infection. Continue reading
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Young Adult With Multivisceral Lesions and Hypoglycemia
A 28-year-old male patient presented with complaints of episodic sweating, palpitation and restlessness for 1 year. He had documented recurrent hypoglycemia which was relieved by consumption of sugars. There was a past history of craniotomy for cerebel… Continue reading
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Young Adult With Multivisceral Lesions and Hypoglycemia
A 28-year-old male patient presented with complaints of episodic sweating, palpitation and restlessness for 1 year. He had documented recurrent hypoglycemia which was relieved by consumption of sugars. There was a past history of craniotomy for cerebel… Continue reading
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Persistent Nonalcoholic Fatty Liver Disease Increases Risk for Carotid Atherosclerosis
Nonalcoholic fatty liver disease (NAFLD) has been associated with subclinical atherosclerosis in cross-sectional studies. We investigated the longitudinal association of NAFLD with the development of subclinical carotid atherosclerosis. Continue reading
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Persistent Nonalcoholic Fatty Liver Disease Increases Risk for Carotid Atherosclerosis
Nonalcoholic fatty liver disease (NAFLD) has been associated with subclinical atherosclerosis in cross-sectional studies. We investigated the longitudinal association of NAFLD with the development of subclinical carotid atherosclerosis. Continue reading
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Effectiveness of Sofosbuvir, Ledipasvir/Sofosbuvir, or Paritaprevir/Ritonavir/Ombitasvir and Dasabuvir Regimens for Treatment of Patients With Hepatitis C in the Veterans Affairs National Health Care System
We investigated the real-world effectiveness of sofosbuvir, ledipasvir/sofosbuvir, and paritaprevir/ritonavir/ombitasvir and dasabuvir (PrOD) in treatment of different subgroups of patients infected with hepatitis C virus (HCV) genotypes 1, 2, 3, or 4. Continue reading
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Effectiveness of Sofosbuvir, Ledipasvir/Sofosbuvir, or Paritaprevir/Ritonavir/Ombitasvir and Dasabuvir Regimens for Treatment of Patients With Hepatitis C in the Veterans Affairs National Healthcare System
We investigated the real-world effectiveness of sofosbuvir, ledipasvir/sofosbuvir, and paritaprevir/ritonavir/ombitasvir and dasabuvir (PrOD) in treatment of different subgroups of patients infected with hepatitis C virus (HCV) genotypes 1, 2, 3, or 4. Continue reading
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Commensal-Specific CD4+ Cells From Patients With Crohn’s Disease Have a T-Helper 17 Inflammatory Profile
Crohn’s disease (CD) has been associated with an altered immune response to commensal microbiota, mostly based on increased seroreactivity to microbial proteins. Although T cells are believed to contribute to the development of CD, little is known ab… Continue reading
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Commensal-specific CD4+ Cells From Patients With Crohn’s Disease Have a T-helper 17 Inflammatory Profile
Crohn’s disease (CD) has been associated with an altered immune response to commensal microbiota, mostly based on increased sero-reactivity to microbial proteins. Although T cells are believed to contribute to development of CD, little is known about… Continue reading
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Covering the Cover
In this phase 2 randomized clinical trial, a twice-daily subcutaneous synthetic ghrelin agonist, relamorelin, significantly reduced vomiting frequency and severity and accelerated gastric emptying in patients with moderate-to-severe diabetic gastropare… Continue reading
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