The ETS-transcription factor ETV1 is involved in the epithelial–mesenchymal transition (EMT) during pancreatic development and is induced in mouse pancreatic intraepithelial neoplasia (PanIN) and pancreatic ductal adenocarcinoma (PDAC). We investigated the function of ETV1 in stromal expansion of PDAC and metastasis, as well as its effects on its downstream target Sparc, which encodes a matricellular protein found in the PDAC stroma that has been associated with invasiveness and metastasis and poor outcomes of patients.