Daily Archives: July 20, 2016

SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations, and Xenograft Tumor Progression in Mice, via Intracellular Synthesis of Aspartate

Posted on July 20, 2016 by Gastroenterology Journal

Many colorectal cancer (CRC) cells contain mutations in KRAS. Analyses of colorectal cancer cells with mutations in APC or CTNNB1 and KRAS identified SLC25A22, which encodes mitochondrial glutamate transporter, as a synthetic lethal gene. We investigat… Continue reading →

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