Daily Archives: July 29, 2016

Jensen CD, Corley DA, Quinn VP, et al. Fecal immunochemical test program performance over 4 rounds of annual screening: a retrospective cohort study. Ann Intern Med 2016;164:456–463. Continue reading →

The gastrointestinal (GI), pancreatic, and hepatic systems work in concert to break down and absorb nutrients, maintain homeostatic glucose levels, and purify the entire bodily organism. Unfortunately, these systems are plagued by many debilitating and… Continue reading →

The 5-hydroxytryptamine receptor 4 (5-HT4R or HTR4) is expressed in the colonic epithelium but little is known about its functions there. We examined whether activation of colonic epithelial 5-HT4R protects colons of mice from inflammation. Continue reading →

Gomm W, von Holt K, Thome F, et al. Association of proton pump inhibitors with risk of dementia. A pharmacoepidemiological claims data analysis. JAMA Neurol 2016;73:410–416. Continue reading →

Anemia is commonly associated with acute and chronic inflammation, but the mechanisms of their interaction are not clear. We investigated whether microRNA 122 (MIR122), which is generated in the liver and is secreted into the blood, is involved in the … Continue reading →

Circadian clocks are present in most organisms and mediate the interplay between the environment and physiologic processes.1 Normally, clocks adjust physiologic responses to anticipated stimuli times. Disruption of circadian clocks/rhythms exacerbates … Continue reading →