Monthly Archives: July 2016

Gomm W, von Holt K, Thome F, et al. Association of proton pump inhibitors with risk of dementia. A pharmacoepidemiological claims data analysis. JAMA Neurol 2016;73:410–416. Continue reading →

Anemia is commonly associated with acute and chronic inflammation, but the mechanisms of their interaction are not clear. We investigated whether microRNA 122 (MIR122), which is generated in the liver and is secreted into the blood, is involved in the … Continue reading →

Circadian clocks are present in most organisms and mediate the interplay between the environment and physiologic processes.1 Normally, clocks adjust physiologic responses to anticipated stimuli times. Disruption of circadian clocks/rhythms exacerbates … Continue reading →

Patients with diabetes have defects in the vagal afferent pathway that result in abnormal gastrointestinal function. We investigated whether selective increased activation of the 2 pore domain potassium channel TRESK contributes to nodose ganglia (NG) … Continue reading →

Aspirin use reduces colorectal cancer risk. Aspirin, a nonsteroidal anti-inflammatory drug, inhibits PTGS2 (cyclooxygenase-2); PTGS2 promotes inflammation and suppresses T cell-mediated adaptive immunity. We investigated whether the inverse association… Continue reading →

The combination of ABT-493 (NS3/4A protease inhibitor) plus ABT-530 (NS5A inhibitor) has shown high rates of sustained virologic response at post-treatment week 12 (SVR12) in noncirrhotic patients infected with hepatitis C virus (HCV) genotypes (GTs) 1… Continue reading →

Celiac disease has been an outlier among intestinal diseases. Although not as prevalent as irritable bowel syndrome, it is significantly more common than inflammatory bowel disease.1 Although patients are rarely hospitalized or undergo surgery due to c… Continue reading →

The Health Resources and Services Administration (HRSA), an agency of the United States Department of Health and Human Services identified fair access and reduction of geographic disparities as the top priorities in the Organ Procurement and Transplan… Continue reading →

The rapid development of new treatments for hepatitis C virus (HCV) has truly been astonishing over the last 3 years with the introduction of all oral direct-acting antivirals (DAAs). Multiple therapeutic regimens are now available for patients depending on viral genotype.1–6 Although no comparative studies exist between regimens, all have very similar overall sustained virologic response (SVR) rates of >95% in a broad range of patients, with the best response in genotype 1 compared with genotypes 2 and 3. Continue reading →

Gruber et al1 demonstrate that YAP/TAZ activity is critical for acinar ductal metaplasia (ADM) by crossing conditional knock-out mice with the well-studied LSL-Kras model of PDAC. They also provide evidence that YAP/TAZ may be sufficient, because ecto… Continue reading →