Monthly Archives: July 2016
Hepatitis B Vaccination: Putting Hepatologists Out of Business?
In this issue of Gastroenterology Chang et al1 from Taiwan describe further outcomes of one of the seismic events in the history of hepatology, namely hepatitis B vaccination. There have been several of these seismic events that have and will continue… Continue reading
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HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant
Chronic infection with hepatitis B virus (HBV) progresses through different phases. The first, called the immune-tolerant phase, has been associated with lack of disease activity. We examined HBV DNA integration, clonal hepatocyte expansion, HBV antige… Continue reading
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Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir
Direct acting antivirals (DAAs) effectively eradicate chronic hepatitis C virus (HCV) infection, although HCV genotype 3a is less responsive to these drugs. We aimed to develop genotype 3a infectious cultures and study the effects of inhibitors of NS5A… Continue reading
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SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations, and Xenograft Tumor Progression in Mice, via Intracellular Synthesis of Aspartate
Many colorectal cancer (CRC) cells contain mutations in KRAS. Analyses of colorectal cancer cells with mutations in APC or CTNNB1 and KRAS identified SLC25A22, which encodes mitochondrial glutamate transporter, as a synthetic lethal gene. We investigat… Continue reading
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Regulation of Transdifferentiation and Retrodifferentiation by Inflammatory Cytokines in Hepatocellular Carcinoma
Liver cancers are typically inflammation-associated cancers characterized by close communication between the tumor cells and the tumor environment. This supportive inflammatory environment contributes to the establishment of a pathological niche consis… Continue reading
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Clinical and Molecular Characteristics of Post-Colonoscopy Colorectal Cancer: A Population-based Study
Colonoscopy provides incomplete protection from colorectal cancer (CRC), but determinants of post-colonoscopy CRC are not well understood. We compared clinical features and molecular characteristics of CRCs diagnosed at different time intervals after a… Continue reading
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A Weight-Management Program for Obese Reflux Patients Is Effective and Improves Symptoms: Interim Analysis of a Clinical Decision Support Tool
Weight-loss counseling for obese patients with gastroesophageal reflux disease (GERD) is an established quality metric, but occurs in a minority of patients. The aim of this quality-improvement initiative was to utilize clinical decision support (CDS) … Continue reading
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A Weight-Management Program for Obese Reflux Patients Is Effective and Improves Symptoms: Interim Analysis of a Clinical Decision Support Tool
Weight-loss counseling for obese patients with gastroesophageal reflux disease (GERD) is an established quality metric, but occurs in a minority of patients. The aim of this quality-improvement initiative was to utilize clinical decision support (CDS) … Continue reading
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Adherence to Guidelines After Poor Colonoscopy Preparation: Experience From a Patient Navigator Program
In 2012, the US Multisociety Task Force (USMSTF) issued guidelines recommending that colonoscopies with poor bowel preparation should be repeated within 1 year. To our knowledge, adherence to guidelines in cases of poor bowel preparation has not been a… Continue reading
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