We are in agreement with Daher et al1 in finding hemochromatosis patients with moderate iron overload who are heterozygous for mutations in the BMP6 pro-peptide. Our unit carries out comprehensive genetic testing for disorders of iron metabolism. This entails a pipeline, the first step of which is to test for the p.Cys282Tyr mutation in the HFE gene. We find approximately 20% of patients are not homozygous for this hemochromatosis-associated mutation. In particular, patients of non-European ancestry fall into this non-C282Y group.