Monthly Archives: August 2016

Experimental studies in acute pancreatitis (AP) suggest a strong association of acinar cell injury with cathepsin B–dependent intracellular activation of trypsin. However, the molecular events subsequent to trypsin activation and their role, if any, … Continue reading →

Pancreatic ductal adenocarcinoma (PDAC) metastasizes to liver at early stages, making this disease highly lethal. TIMP metallopeptidase inhibitor 1 (TIMP1) creates a metastasis-susceptible environment in the liver. We investigated the role of TIMP1 and… Continue reading →

Pancreatic ductal adenocarcinoma (PDAC) metastasizes to liver at early stages, making this disease highly lethal. TIMP metallopeptidase inhibitor 1 (TIMP1) creates a metastasis-susceptible environment in the liver. We investigated the role of TIMP1 and… Continue reading →

We thank those who wrote in regard to our study “Rectal Indomethacin Does not Prevent Post-ERCP Pancreatitis (PEP) in Consecutive Patients” which was recently published in Gastroenterology.1 Clearly this is an important topic, and I appreciate the … Continue reading →

We thank the authors who have responded to our recent work on the relationship between anesthesia services and short-term colonoscopy outcomes,1 and welcome the opportunity to respond to their questions concerning our methods and interpretation. Continue reading →

Question: A 35-year-old black man with no past medical history presented to the emergency room with complaints of fever, abdominal pain, malaise, and vomiting, for a week. Physical examination was significant for a temperature of 103.2°F, pulse of 102… Continue reading →

A 47-year-old woman presented with new-onset hematuria, easy bruising, and abdominal pain. For the past 10 days, she had severe, watery diarrhea and right-sided flank pain radiating to the right lower quadrant (RLQ) of her abdomen. She recently returne… Continue reading →

Question: A 52-year-old man with a history of hypertension and diabetes mellitus was admitted because of right upper abdominal pain of 3 days’ duration. He complained of nausea, abdominal fullness, and fever. He also noted that his skin had become ye… Continue reading →

Question: A 48-year-old woman presents with recurrent ascites and progressive weakness. She was discharged a little over a week ago and at that time multiple diagnostic studies, including a large volume paracentesis (serum ascites–albumin gradient [S… Continue reading →

Question: A 35-year-old previously well woman underwent colonoscopy as part of a health checkup. She took liquid sodium phosphate solution for colon preparation. She noted no abdominal pain or bloody stool before or after taking the colon preparation. … Continue reading →