Monthly Archives: August 2016

Few treatments have demonstrated efficacy and safety for diarrhea-predominant irritable bowel syndrome (IBS-D). A phase 3, randomized, double-blind, placebo-controlled trial was performed to evaluate the safety and efficacy of repeat treatment with the… Continue reading →

A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted … Continue reading →

A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted … Continue reading →

Little is known about the origin of pancreatic intraductal papillary mucinous neoplasms (IPMN). Pancreatic duct glands (PDGs) are gland-like outpouches budding off the main pancreatic ducts that function as progenitor niche for the ductal epithelium; t… Continue reading →

Little is known about the origin of pancreatic intraductal papillary mucinous neoplasms (IPMN). Pancreatic duct glands (PDGs) are gland-like outpouches budding off the main pancreatic ducts that function as progenitor niche for the ductal epithelium; t… Continue reading →

The gastrointestinal (GI) tract is essential for the absorption of nutrients, induction of mucosal and systemic immune responses and maintenance of a healthy gut microbiota. Key aspects of gastrointestinal physiology are controlled by the enteric nervo… Continue reading →

The gastrointestinal (GI) tract is essential for the absorption of nutrients, induction of mucosal and systemic immune responses and maintenance of a healthy gut microbiota. Key aspects of gastrointestinal physiology are controlled by the enteric nervo… Continue reading →

There are few validated biomarkers that can be used to predict outcomes of patients with colorectal cancer. Part of the challenge is the genetic and molecular heterogeneity of colorectal tumors not only among patients, but also within tumors. We have e… Continue reading →

There are few validated biomarkers that can be used to predict outcomes of patients with colorectal cancer. Part of the challenge is the genetic and molecular heterogeneity of colorectal tumors not only among patients, but also within tumors. We have e… Continue reading →

Experimental studies in acute pancreatitis (AP) suggest a strong association of acinar cell injury with cathepsin B–dependent intracellular activation of trypsin. However, the molecular events subsequent to trypsin activation and their role, if any, … Continue reading →