Monthly Archives: September 2016

IGF2 is Upregulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and is an Actionable Oncogene Product in Experimental Models

Effective treatments are urgently needed for hepatocellular carcinoma (HCC), which is usually diagnosed at advanced stages. Signaling via the insulin-like growth factor (IGF) pathway is aberrantly activated in HCC by IGF2 overexpression. We aimed to el… Continue reading

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Unusual Esophageal Foreign Body

Question: A 38-year-old man presented with complaints of mild dysphagia after the ingestion of a dinner fork about 1.5 hours ago, while attempting to induce vomiting. Physical examination was unremarkable, with no hypersialosis or subcutaneous emphysem… Continue reading

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Unusual Esophageal Foreign Body

Question: A 38-year-old man presented with complaints of mild dysphagia after the ingestion of a dinner fork about 1.5 hours ago, while attempting to induce vomiting. Physical examination was unremarkable, with no hypersialosis or subcutaneous emphysem… Continue reading

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An Unusual Cause of Dysphagia and Melena

Question: A 51-year-old man complained of a dry cough, dysphagia, odynophagia, and melena for 10 months. He had a >30 pack-years smoking history, but did not consume an excessive amount of alcohol. He had no history of dyspnea, respiratory tract bleeding, or massive hemorrhage of the gastrointestinal tract. No clinically important signs were found during physical examination. Laboratory results exhibited a positive hemoccult stool test and mild anemia (hemoglobin, 107 g/L). The patient was found to have a large, soft tissue density mass in the upper esophagus on a computed tomography scan (Figure A, white arrow). Continue reading

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An Unusual Cause of Dysphagia and Melena

Question: A 51-year-old man complained of a dry cough, dysphagia, odynophagia, and melena for 10 months. He had a >30 pack-years smoking history, but did not consume an excessive amount of alcohol. He had no history of dyspnea, respiratory tract bleeding, or massive hemorrhage of the gastrointestinal tract. No clinically important signs were found during physical examination. Laboratory results exhibited a positive hemoccult stool test and mild anemia (hemoglobin, 107 g/L). The patient was found to have a large, soft tissue density mass in the upper esophagus on a computed tomography scan (Figure A, white arrow). Continue reading

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An Unusual Cause of Splenomegaly

A 58-year-old Indian man presented with one-month history of dull pain and mass in the left upper quadrant of abdomen. There was no history of fever or weight loss. Clinical examination revealed splenomegaly. Hemoglobin, renal and liver function tests … Continue reading

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An Unusual Cause of Splenomegaly

A 58-year-old Indian man presented with one-month history of dull pain and mass in the left upper quadrant of abdomen. There was no history of fever or weight loss. Clinical examination revealed splenomegaly. Hemoglobin, renal and liver function tests … Continue reading

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Repeated Hepatolithiasis and Unknown Mass in Cholangiography

Question: A 68-year-old woman was admitted for persistent high fever and cutaneous abscess with a history of cholecystectomy for cholelithiasis and a hepatic left lateral lobectomy for hepatolithiasis. A subcostal incision scar, 15 cm long, was observe… Continue reading

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Repeated Hepatolithiasis and Unknown Mass in Cholangiography

Question: A 68-year-old woman was admitted for persistent high fever and cutaneous abscess with a history of cholecystectomy for cholelithiasis and a hepatic left lateral lobectomy for hepatolithiasis. A subcostal incision scar, 15 cm long, was observe… Continue reading

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