Daily Archives: November 23, 2016

As a surgical pathologist, I have concentrated on the study and diagnosis of gastrointestinal (GI) diseases for 50 years. During my training, there were only a few pathologists worldwide who were known for their expertise in GI diseases, including Basi… Continue reading →

As a surgical pathologist, I have concentrated on the study and diagnosis of gastrointestinal (GI) diseases for 50 years. During my training, there were only a few pathologists worldwide who were known for their expertise in GI diseases, including Basi… Continue reading →

Tumor necrosis factor (TNF) is a cytokine that promotes inflammation and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and tissues, intestinal epithelial cells undergo rapid cell death upon exposure to TNF, by unclear m… Continue reading →

Tumor necrosis factor (TNF) is a cytokine that promotes inflammation and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and tissues, intestinal epithelial cells undergo rapid cell death upon exposure to TNF, by unclear m… Continue reading →

Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial to assess the ability of budesonide oral suspension (BOS… Continue reading →

Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial to assess the ability of budesonide oral suspension (BOS… Continue reading →

Chen JW, Pandolfino JE, Lin Z, et al. Severity of endoscopically identified esophageal rings correlates with reduced esophageal distensibility in eosinophilic esophagitis. Endoscopy 2016;48:1–8. Continue reading →

Chen JW, Pandolfino JE, Lin Z, et al. Severity of endoscopically identified esophageal rings correlates with reduced esophageal distensibility in eosinophilic esophagitis. Endoscopy 2016;48:1–8. Continue reading →

Hepatocellular carcinoma (HCC) is characterized by distinct interpatient tumor heterogeneity,1 and patients often respond in markedly different ways to treatment or show drug resistance. This complexity is further emphasized by intratumor heterogeneity… Continue reading →

The last decade has seen a surge in investigation of stem cell populations in the gastrointestinal tract, establishing LGR5 as the gold standard marker of active stem cells in the bases of intestinal crypts.1 Other stem cell markers, including HOPX, BM… Continue reading →