Daily Archives: November 23, 2016
Isthmus Time Is Here: Runx1 Identifies Mucosal Stem Cells in the Gastric Corpus
The last decade has seen a surge in investigation of stem cell populations in the gastrointestinal tract, establishing LGR5 as the gold standard marker of active stem cells in the bases of intestinal crypts.1 Other stem cell markers, including HOPX, BM… Continue reading
SMAD About Hepatitis C Virus Cell Entry and Liver Disease
Hepatitis C virus (HCV) remains a major global health burden, with approximately 150 million people persistently infected. Chronically infected individuals are at increased risk for severe progressive liver disease, including cirrhosis and hepatocellul… Continue reading
SMAD About Hepatitis C Virus Cell Entry and Liver Disease
Hepatitis C virus (HCV) remains a major global health burden, with approximately 150 million people persistently infected. Chronically infected individuals are at increased risk for severe progressive liver disease, including cirrhosis and hepatocellul… Continue reading
“New” Cancer Genes and Inherited Colorectal Cancer Risk: Caveat Emptor
Familial adenomatous polyposis (FAP) and the Lynch syndrome are the most common and well-known high-penetrance genetic syndromes that confer inherited risks of colorectal cancer (CRC). In each case, the culpable genes were identified by linkage studies… Continue reading
“New” Cancer Genes and Inherited Colorectal Cancer Risk: Caveat Emptor
Familial adenomatous polyposis (FAP) and the Lynch syndrome are the most common and well-known high-penetrance genetic syndromes that confer inherited risks of colorectal cancer (CRC). In each case, the culpable genes were identified by linkage studies… Continue reading
Incidence of Hepatocellular Carcinoma in All 50 United States, From 2000 Through 2012
The incidence and mortality of hepatocellular carcinoma (HCC) have been reported to be plateauing in the United States. The United States has large racial, ethnic, and regional variation; we collected data from all 50 states to better analyze changes i… Continue reading
Incidence of Hepatocellular Carcinoma in all 50 United States, From 2000 Through 2012
The incidence and mortality of hepatocellular carcinoma (HCC) have been reported to be plateauing in the United States (US). The US has large racial, ethnic, and regional variation; we collected data from all 50 states to better analyze changes in inci… Continue reading
Inflammatory Bowel Disease: A Global Disease That Needs a Broader Ensemble of Populations
Inflammatory bowel diseases (IBD) are emerging in newly industrialized countries in Asia, South America, and the Middle East and, therefore, IBD has evolved into a global disease. With such an increasing prevalence in every continent, the costs of heal… Continue reading
Inflammatory Bowel Disease: A Global Disease That Needs a Broader Ensemble of Populations
Inflammatory bowel diseases (IBD) are emerging in newly industrialized countries in Asia, South America, and the Middle East and, therefore, IBD has evolved into a global disease. With such an increasing prevalence in every continent, the costs of heal… Continue reading
How to Prepare for and Write a Grant: Personal Perspectives
Success in academic medicine is driven in large part by obtaining grant funding. Resources are limited even in the best of circumstances; therefore, competition is frequently fierce. Herein we outline our personal perspectives1 gained over decades of … Continue reading