We thank you for the insightful comments in regard to our study “Rectal Indomethacin Reduces Pancreatitis in High- and Low-Risk Patients Undergoing Endoscopic Retrograde Cholangiopancreatography” published in Gastroenterology in August 2016.1 Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is an important topic and we appreciate the opportunity to respond to the letter submitted by George et al.