Monthly Archives: December 2016
Occult Hepatitis C Virus Infection: Are We Digging Too Deep?
Occult hepatitis C virus (HCV) infection (OCI) is the detection of HCV RNA in either liver tissue or peripheral blood mononuclear cells (PBMC) despite repeatedly undetectable levels of HCV RNA in serum.1 From a clinical perspective, OCI has been linked… Continue reading
Occult Hepatitis C Virus Infection: Are We Digging Too Deep?
Occult hepatitis C virus (HCV) infection (OCI) is the detection of HCV RNA in either liver tissue or peripheral blood mononuclear cells (PBMC) despite repeatedly undetectable levels of HCV RNA in serum.1 From a clinical perspective, OCI has been linked… Continue reading
Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients with Gastric Cancer
Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with here… Continue reading
Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients with Gastric Cancer
Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with here… Continue reading
Patients With Barrett’s Esophagus and Confirmed Persistent Low-grade Dysplasia at Increased Risk for Progression to Neoplasia
For patients with Barrett’s esophagus (BE), the diagnosis of low-grade dysplasia (LGD) is subjective and reported outcomes vary. We analyzed data from a multicenter study of endoscopic therapy to identify factors associated progression to high-grade … Continue reading
Patients With Barrett’s Esophagus and Confirmed Persistent Low-grade Dysplasia at Increased Risk for Progression to Neoplasia
For patients with Barrett’s esophagus (BE), the diagnosis of low-grade dysplasia (LGD) is subjective and reported outcomes vary. We analyzed data from a multicenter study of endoscopic therapy to identify factors associated progression to high-grade … Continue reading
Detection of Sessile Serrated Adenomas in Proximal Colon Using Wide-field Fluorescence Endoscopy
Many cancers in the proximal colon develop via from sessile serrated adenomas (SSAs), which have flat, subtle features that are difficult to detect with conventional white-light colonoscopy. Many SSA cells have the V600E mutation in BRAF. We investigat… Continue reading
Detection of Sessile Serrated Adenomas in Proximal Colon Using Wide-field Fluorescence Endoscopy
Many cancers in the proximal colon develop via from sessile serrated adenomas (SSAs), which have flat, subtle features that are difficult to detect with conventional white-light colonoscopy. Many SSA cells have the V600E mutation in BRAF. We investigat… Continue reading
Rifaximin Reduces Number and Severity of Intestinal Lesions Associated With use of Non-steroidal Anti-inflammatory Drugs in Humans
The intestinal microbiota might contribute to enteropathy associated with use of non-steroidal anti-inflammatory drugs (NSAIDs), but there have been few human studies of this association. We performed a placebo-controlled study to determine whether a d… Continue reading
Rifaximin Reduces Number and Severity of Intestinal Lesions Associated With use of Non-steroidal Anti-inflammatory Drugs in Humans
The intestinal microbiota might contribute to enteropathy associated with use of non-steroidal anti-inflammatory drugs (NSAIDs), but there have been few human studies of this association. We performed a placebo-controlled study to determine whether a d… Continue reading