Monthly Archives: January 2017
Seventy Years of Polyethylene Glycols in Gastroenterology: The Journey of PEG 4000 and 3350 From Nonabsorbable Marker to Colonoscopy Preparation to Osmotic Laxative
The history of polyethylene glycols (PEGs) began in 1859 when Laurenco heated ethylene glycol and 1,2-dibromoethane and isolated oligo(ethylene glycol)s by fractional distillation.1 PEGs are synthetic, uncharged, nonbranched, hydrophilic polymers made … Continue reading
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Seventy Years of Polyethylene Glycols in Gastroenterology: The Journey of PEG 4000 and 3350 From Nonabsorbable Marker to Colonoscopy Preparation to Osmotic Laxative
The history of polyethylene glycols (PEGs) began in 1859 when Laurenco heated ethylene glycol and 1,2-dibromoethane and isolated oligo(ethylene glycol)s by fractional distillation.1 PEGs are synthetic, uncharged, nonbranched, hydrophilic polymers made … Continue reading
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Current Challenges and Emerging Solutions in Upper GI Disorders: A Brief Report of the 2016 AGA Drug Development Conference
In October 2016, the Center for Diagnostics and Therapeutics (CDT) of the American Gastroenterological Association (AGA) held its first Drug Development Conference. Over a 2-day period, researchers, clinicians, Food and Drug Administration (FDA) person… Continue reading
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Current Challenges and Emerging Solutions in Upper GI Disorders: A Brief Report of the 2016 AGA Drug Development Conference
In October 2016, the Center for Diagnostics and Therapeutics (CDT) of the American Gastroenterological Association (AGA) held its first Drug Development Conference. Over a 2-day period, researchers, clinicians, Food and Drug Administration (FDA) person… Continue reading
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Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via Wnt Signaling and Stabilization of Low Density Lipoprotein Receptor-related Proteins 5 and 6
Stearoyl-CoA desaturase (SCD) synthesizes monounsaturated fatty acids (MUFAs) and has been associated with development of metabolic syndrome, tumorigenesis, and stem cell characteristics. We investigated whether and how SCD promotes liver fibrosis and … Continue reading
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Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via Wnt Signaling and Stabilization of Low Density Lipoprotein Receptor-related Proteins 5 and 6
Stearoyl-CoA desaturase (SCD) synthesizes monounsaturated fatty acids (MUFAs) and has been associated with development of metabolic syndrome, tumorigenesis, and stem cell characteristics. We investigated whether and how SCD promotes liver fibrosis and … Continue reading
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Tumor Potentiating Mechanisms of Fusobacterium nucleatum, A Multifaceted Microbe
Fusobacterium nucleatum is an unlikely candidate for a cancer-instigating microbe. For years, F nucleatum has been regarded as a common constituent of the commensal oral microbiome and recognized as one of many different microbes associated with gingiv… Continue reading
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Tumor Potentiating Mechanisms of Fusobacterium nucleatum, A Multifaceted Microbe
Fusobacterium nucleatum is an unlikely candidate for a cancer-instigating microbe. For years, F nucleatum has been regarded as a common constituent of the commensal oral microbiome and recognized as one of many different microbes associated with gingiv… Continue reading
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The Best Laid Plans: Adaptation is an Essential Part of Going From Efficacy Research to Program Implementation
Colorectal cancer (CRC) screening is widely recommended, but underused. The US Preventive Services Task Force (USPSTF) has given CRC screening an A grade, its highest possible recommendation. Owing to a lack of clear evidence of superiority, the list o… Continue reading
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The AGA’s Fecal Microbiota Transplantation National Registry: An Important Step Toward Understanding Risks and Benefits of Microbiota Therapeutics
Fecal microbiota transplantation (FMT) is the delivery of stool from a healthy donor to a recipient with the goal of mitigating disease by modifying the structure and/or function of the gut microbiome. This shotgun approach has proven to be a highly ef… Continue reading
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