Monthly Archives: January 2017
Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric Bypass
Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) is generally attributed to fat malabsorption. If hyperoxaluria is indeed caused by fat malabsorption, magnitudes of hyperoxaluria and steatorrhea should correlate. Severely obese patients, prior to by… Continue reading
Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric Bypass
Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) is generally attributed to fat malabsorption. If hyperoxaluria is indeed caused by fat malabsorption, magnitudes of hyperoxaluria and steatorrhea should correlate. Severely obese patients, prior to by… Continue reading
Activation of the Hypoxia Inducible Factor 1 Alpha Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones
Hypoxia inducible factor 1 alpha subunit (HIF1A) is a transcription factor that controls the cellular response to hypoxia and is activated in hepatocytes of patients with non-alcoholic fatty liver disease (NAFLD). NAFLD increases risk for cholesterol g… Continue reading
Activation of the Hypoxia Inducible Factor 1 Alpha Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones
Hypoxia inducible factor 1 alpha subunit (HIF1A) is a transcription factor that controls the cellular response to hypoxia and is activated in hepatocytes of patients with non-alcoholic fatty liver disease (NAFLD). NAFLD increases risk for cholesterol g… Continue reading
Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice
It is a challenge to deliver nucleic acids to gastrointestinal (GI) tissues due to their size and need for intracellular delivery. They are also extremely susceptible to degradation by nucleases, which are ubiquitous in the GI tract. We investigated wh… Continue reading
Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice
It is a challenge to deliver nucleic acids to gastrointestinal (GI) tissues due to their size and need for intracellular delivery. They are also extremely susceptible to degradation by nucleases, which are ubiquitous in the GI tract. We investigated wh… Continue reading
Changes in the Prevalence of Hepatitis C Virus Infection, Non-alcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients with Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation
Concurrent to development of more effective drugs for treatment of hepatitis C virus (HCV), infection, there has been an increase in the incidence of non-alcoholic fatty liver disease (NAFLD). Data indicate that liver transplantation prolongs survival … Continue reading
Changes in the Prevalence of Hepatitis C Virus Infection, Non-alcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients with Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation
Concurrent to development of more effective drugs for treatment of hepatitis C virus (HCV), infection, there has been an increase in the incidence of non-alcoholic fatty liver disease (NAFLD). Data indicate that liver transplantation prolongs survival … Continue reading
X-box Binding Protein 1 Regulates Unfolded Protein, Acute-phase, and DNA Damage Responses During Regeneration of Mouse Liver
Liver regeneration after partial hepatectomy increases the protein folding burden at the endoplasmic reticulum (ER) of remnant hepatocytes, resulting in induction of the unfolded protein response (UPR). We investigated the role of the core UPR transcri… Continue reading
X-box Binding Protein 1 Regulates Unfolded Protein, Acute-phase, and DNA Damage Responses During Regeneration of Mouse Liver
Liver regeneration after partial hepatectomy increases the protein folding burden at the endoplasmic reticulum (ER) of remnant hepatocytes, resulting in induction of the unfolded protein response (UPR). We investigated the role of the core UPR transcri… Continue reading