Colorectal cancer (CRC) screening is widely recommended, but underused. The US Preventive Services Task Force (USPSTF) has given CRC screening an A grade, its highest possible recommendation. Owing to a lack of clear evidence of superiority, the list of recommended tests included 7 different strategies, without identification of a preferred strategy or set of strategies.1 The USPSTF recommendation is based on randomized, controlled trial (RCT) evidence of efficacy of guaiac fecal occult blood tests and flexible sigmoidoscopy for reducing the incidence and mortality of CRC.