Monthly Archives: February 2017
MAN2A1–FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice
Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1−FER. We investigated w… Continue reading
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MAN2A1–FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice
Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1−FER. We investigated w… Continue reading
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Features of Patients With Hereditary Mixed Polyposis Syndrome Caused by Duplication of GREM1 and Implications for Screening and Surveillance
Hereditary mixed polyposis syndrome is a rare colon cancer predisposition syndrome caused by a duplication of a non-coding sequence near the gremlin 1, DAN family BMP antagonist gene (GREM1) originally described in Ashkenazi Jews. Few families with GRE… Continue reading
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Lower Prevalence of Celiac Disease and Gluten-Related Disorders in Persons Living in Southern vs Northern Latitudes of the United States
The association between prevalence of celiac disease and geographic region is incompletely understood, but the occurrence of several autoimmune disorders has been found to vary along a North–South gradient. We examined geographic, demographic, and cl… Continue reading
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Association Between Screen-detected Gallstone Disease and Cancer in a Cohort Study
In a general population screened for gallstones through ultrasound examination, gallstones were associated with the development of pooled gastrointestinal cancers and, in particular, right-side colon cancer. Continue reading
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Factors Associated With Shorter Colonoscopy Surveillance Intervals for Patients With Low-risk Colorectal Adenomas and Effects on Outcome
Endoscopists do not routinely follow guidelines to survey individuals with low-risk adenomas (LRAs, 1–2 small tubular adenomas, less than 1 cm) every 5–10 years for colorectal cancer (CRC)—many endoscopists recommend shorter surveillance interval… Continue reading
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Hepatitis B reactivation associated with immune suppressive and biological modifier therapies: current concepts, management strategies and future directions
Hepatitis B reactivation associated with immune suppressive and biological therapies is emerging to be an important cause of morbidity and mortality in patients with current or prior exposure to hepatitis B virus infection. The population at risk for H… Continue reading
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Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia and NAFLD
Bile acids are signaling molecules, which coordinately regulate metabolism and inflammation via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5). These receptors activate transcriptional networks and signaling c… Continue reading
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“Is there an optimal diet for weight management and metabolic health?”
Individuals can lose body weight and improve health status on a wide range of energy (calorie) restricted dietary interventions. In this paper, we have reviewed the effectiveness of the most commonly utilized diets, including low-fat, low-carbohydrate … Continue reading
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Recent advances in human genetics and epigenetics of adiposity: pathway to precision medicine?
Obesity is a heritable trait that contributes to substantial global morbidity and mortality. Here, we summarize findings from the last decade of genetic and epigenetic research focused on unravelling the underpinnings of adiposity. More than 140 geneti… Continue reading
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