Monthly Archives: February 2017
Context-dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity
The ability of exocrine pancreatic cells to change the cellular phenotype is required for tissue regeneration upon injury but also contributes to their malignant transformation and tumor progression. We investigated context-dependent signaling and tran… Continue reading
Association Between High-avidity T-cell Receptors, Induced by Alpha Fetoprotein-derived Peptides, and Anti-tumor Effects in Patients with Hepatocellular Carcinoma
Levels of alpha fetoprotein (AFP) are measured for surveillance and diagnosis of hepatocellular carcinoma (HCC). We performed a phase 1 trial to evaluate the safety and efficacy of AFP-derived peptides as an anti-tumor vaccine for patients with advance… Continue reading
High incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes
Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area. Continue reading
Genome-wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection
There is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with anti-viral agents. We investigated genetic factors associated with the development of HCC in patients with a sustained viro… Continue reading
Doppler Endoscopic Probe Monitoring of Blood Flow Improves Risk Stratification and Outcomes of Patients with Severe Non-Variceal Upper Gastrointestinal Hemorrhage
For 4 decades, stigmata of recent hemorrhages in patients with non-variceal lesions have been used for risk stratification and endoscopic hemostasis. The arterial blood flow that underlies the stigmata is rarely monitored, but can be used to determine … Continue reading
Information for Authors and Readers
Gastroenterology is the premiere journal in theĀ fieldĀ of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverag… Continue reading
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Because our study was a retrospective cohort study, the diagnosis of lower gastrointestinal (GI) bleeding was largely by exclusion rather than by direct confirmation of the source of bleeding. A lower GI investigation was not performed on every patient… Continue reading