Acute pancreatitis is the most common gastrointestinal reason for acute hospitalization.1 Approximately 20% of patients with acute pancreatitis develop necrotizing pancreatitis.2,3 In approximately 30% of these patients, secondary infection of the necrosis occurs, which almost always requires an invasive intervention.4,5 Diagnosing infected necrosis on clinical grounds can be difficult. Furthermore, even if infected necrosis is proven, international guidelines advise to postpone invasive intervention to around 4 weeks after disease onset.