Monthly Archives: March 2017

It is with great interest that we read the publication written by Salem et al1: “Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma.” This article gave results… Continue reading →

We read with great interest the paper “Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma.”1 We commend the authors for studying this very important subject in … Continue reading →

In a study of 138 treatment-naïve pediatric inflammatory bowel disease patients and 49 controls, rectal expression of type 2 and type 17 immune response genes discriminated ulcerative colitis from Crohn’s colitis and was associated with clinical out… Continue reading →

Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription factors that contain conserved zinc finger domains involved in binding to target DNA sequences. Many of these proteins are expressed in different tissues … Continue reading →

Over the last 5 decades, advances in devices and techniques have enhanced the success of selective biliary cannulation (SBC). “Diagnostic” endoscopic retrograde cholangiopancreatography (ERCP) has been largely replaced by excellent noninvasive im… Continue reading →

We investigated how many patients with a diagnosis of non-celiac wheat sensitivity (NCWS) still experienced wheat sensitivity after a median follow-up time of 99 months. We collected data from 200 participants from a previous study of NCWS, performed between July and December 2016 in Italy;148 of these individuals were still on a strict wheat-free diet. In total, 175 patients (88%) improved (had fewer symptoms) after a diagnosis of NCWS; 145 of 148 patients who adhered strictly to a gluten-free diet (98%) had reduced symptoms, compared to 30 of 52 patients who did not adhere to a gluten-free diet (58%) (P<.0001). Continue reading →

Esophageal squamous cell carcinoma (ESCC) is most common subtype of esophageal cancer. Little is known about the genetic changes that occur in esophageal cells during development of ESCC. We performed next-generation sequence analyses of esophageal non… Continue reading →

The US Multi-Society Task Force on Colorectal Cancer, with invited experts, developed a consensus statement and recommendations to assist health care providers with appropriate management of patients with biallelic mismatch repair deficiency (BMMRD)… Continue reading →

There is growing interest in the use of bone marrow cells to treat liver fibrosis, however little is known about their anti-fibrotic efficacy or the identity of their effector cell(s). Sphingosine-1-phosphate (S1P) mediates egress of immune cells from … Continue reading →

Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immuneparesis) and are susceptible to sepsis. Cytotoxic T-lymphocyte associated protein 4 (CTLA4), which interacts with the membrane receptor B7 (also called C… Continue reading →