Daily Archives: March 28, 2017
Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer
The US Multi-Society Task Force on Colorectal Cancer, with invited experts, developed a consensus statement and recommendations to assist health care providers with appropriate management of patients with biallelic mismatch repair deficiency (BMMRD)… Continue reading
Sphingosine-1-phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis
There is growing interest in the use of bone marrow cells to treat liver fibrosis, however little is known about their anti-fibrotic efficacy or the identity of their effector cell(s). Sphingosine-1-phosphate (S1P) mediates egress of immune cells from … Continue reading
Increased Expression of CTLA4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure
Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immuneparesis) and are susceptible to sepsis. Cytotoxic T-lymphocyte associated protein 4 (CTLA4), which interacts with the membrane receptor B7 (also called C… Continue reading
Hepatocellular Carcinoma After Sustained Virologic Response: Leave No One Behind
The global burden of disease attributable to viral hepatitis is increasing. In 2013, viral hepatitis was the seventh leading cause of death worldwide, owing to cirrhosis and hepatocellular carcinoma (HCC).1 HCC is the fastest increasing cause of cancer… Continue reading
Our New President— Sheila E. Crowe, MD
This may be the first time that the incoming president of the AGA has been introduced by a colleague who is also their spouse. I have known Sheila as her lab partner in college, husband, collaborator and still, her lab partner. We have car-pooled to wo… Continue reading
Genetic Features of Aflatoxin-associated Hepatocellular Carcinomas
Dietary exposure to aflatoxin is an important risk factor for hepatocellular carcinoma (HCC). However, little is known about the genomic features and mutations of aflatoxin-associated HCCs compared with HCCs not associated with aflatoxin exposure. We i… Continue reading
Juan Rodés—In Memoriam
“Where there is no vision, the people disappear”—King Solomon Proverbs Continue reading