Monthly Archives: March 2017

Activation of Epithelial STAT1 by Interleukin 28 Controls Mucosal Healing in Mice with Colitis and is Increased in Mucosa of Patients With Inflammatory Bowel Disease

Posted on March 22, 2017 by Gastroenterology Journal

We investigated the roles of interleukin 28A (also called IL28A or interferon lambda 2) in intestinal epithelial cell (IEC) activation, studying its effects in mouse models of inflammatory bowel diseases (IBD) and intestinal mucosal healing. Continue reading →

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The AGA/Funderburg Award in Gastric Cancer: Twenty-five years of advances in gastric cancer research

Posted on March 19, 2017 by Gastroenterology Journal
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Direct-Acting Antivirals for Chronic Hepatitis C: Can Drug Properties Signal Potential for Liver Injury?

Posted on March 19, 2017 by Gastroenterology Journal
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Biallelic Mismatch Repair Deficiency Syndrome– Management and Prevention of a Devastating Manifestation of Lynch syndrome

Posted on March 19, 2017 by Gastroenterology Journal
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US-Cuba research collaborations: opening bridges for gastroenterology

Posted on March 19, 2017 by Gastroenterology Journal
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Academic Gastroenterology Practice in a Value-Based World: One Size No Longer Fits All

Posted on March 18, 2017 by Spencer D. Dorn
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Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

Posted on March 16, 2017 by Gastroenterology Journal

The desmoplasia and poor vascularity cause severe metabolic stress in pancreatic ductal adenocarcinomas (PDACs). Serotonin (5-HT) is a neuromodulator with neurotransmitter and neuroendocrine functions that contributes to tumorigenesis. We investigated … Continue reading →

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Efficacy and Safety of Sofosbuvir plus Daclatasvir for Treatment of HCV-associated Cryoglobulinemia Vasculitis

Posted on March 10, 2017 by Gastroenterology Journal

Circulating mixed cryoglobulins are detected in 40%–60% of patients with hepatitis C virus (HCV) infection, and overt cryoglobulinemia vasculitis (CryoVas) develops in about 15% of patients. Remission of vasculitis has been associated with viral clea… Continue reading →

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Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition

Posted on March 9, 2017 by Gastroenterology Journal

Drugs that inhibit the erb-b2 receptor tyrosine kinase 2 (ERBB2 or HER2) are the standard treatment of patients with different types of cancer, including HER2-overexpressing gastroesophageal tumors. Unfortunately, cancer cells become resistant to these… Continue reading →

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Using a 3% Proton Density Fat Fraction as a Cut-off Value Increases Sensitivity of Detection of Hepatic Steatosis, Based on Results from Histopathology Analysis

Posted on March 9, 2017 by Gastroenterology Journal

It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy (1H-MRS), instead of collecting and analyzing liver biopsies to detect steatosis. However, the c… Continue reading →

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