Monthly Archives: March 2017

It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy (1H-MRS), instead of collecting and analyzing liver biopsies to detect steatosis. However, the c… Continue reading →

Drug repositioning offers a shorter approval process than new drug development. We therefore searched large public datasets of drug-induced gene expression signatures to identify agents that might be effective against hepatocellular carcinoma (HCC). Continue reading →

Little is known about provider and health system factors that affect receipt of active therapy and outcomes of patients with hepatocellular carcinoma (HCC). We investigated patient, provider, and health system factors associated with receipt of active … Continue reading →

A novel, fluorescently labeled peptide topically administered to the proximal colon distinguished sessile serrated adenomas from normal colonic mucosa with 89% sensitivity and 92% specificity in a small trial. Continue reading →

Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large, international cohort of pa… Continue reading →

Interferon-free direct-acting antiviral (DAA) therapies are effective in patients with hepatitis C virus-induced cryoglobulinemia vasculitis (HCV-CV). We analyzed blood samples from patients with HCV-CV before and after DAA therapy to determine mechani… Continue reading →

Question: A 14-year-old girl of African descent, presented with severe abdominal pain at the pediatric department. The pain had started 3 days earlier and initially was intermittent, diffuse, and cramping. At presentation it had become continuous, prog… Continue reading →

Question: A 71-year-old woman with a past medical history of living unrelated donor transplant done 15 years ago for primary biliary cirrhosis was referred for evaluation of dysphagia. Dysphagia was primarily to solid foods and later progressed to thic… Continue reading →

Question: A 47-year-old woman was referred to our department for a liver mass. She had a significant past history of being a hepatitis B carrier on yearly abdominal ultrasound imaging in an outpatient setting. Her last abdominal ultrasound was performe… Continue reading →

In 1985, Drs Chu, Liaw, and colleagues described the first phase of chronic hepatitis, referred to as immune tolerant (IT), as “The high replicative phase, characterized by HBeAg reactivity in serum and only minor histologic activity,” including no… Continue reading →