Daily Archives: April 28, 2017

The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations

“Thank you for removing those polyps during the colonoscopy today. If I change my diet, can I reduce the risk of developing more polyps or colon cancer in the future?” This is one of the most commonly posed questions by our patients, after being in… Continue reading

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Young-Onset Colorectal Cancer: Earlier Diagnoses or Increasing Disease Burden?

Colorectal cancer (CRC) incidence and mortality in the United States have changed strikingly in recent decades. Overall, CRC incidence decreased by >30% from 1975 (59.5 per 100,000) to 2013 (37.9 per 100,000).1 CRC mortality similarly declined from 28.1 per 100,000 in 1975 to 14.5 per 100,000 in 2013—nearly a 50% decrease.1 Screen-eligible populations, particularly those over age 65, have experienced the largest declines in incidence and mortality.2,3 Continue reading

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Gallstone Disease and Cancer Risk: Finding the Bug in the System

Bile acid synthesis and composition is tightly controlled through the mechanisms involved in the enterohepatic circulation, also referred to as the gut–microbiota–liver axis (Figure 1A). Disruptions in the balance—be it through genetic, metabol… Continue reading

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