Monthly Archives: April 2017

The incidence of Clostridium difficile infection (CDI) has increased in the past decade, despite intensified efforts at prevention including infection control and antimicrobial stewardship.1 This has led to the exploration of additional means to reduce… Continue reading →

A diagnosis of celiac disease is made based on clinical, genetic, serologic, and duodenal morphology features. Recent pediatric guidelines, based largely on retrospective data, propose omitting biopsy analysis for patients with concentrations of immuno… Continue reading →

Over the last 4 decades, advances in surgical techniques, locoregional therapy imaging, and systemic therapy have significantly improved overall survival (OS) in hepatocellular carcinoma (HCC).1 HCC’s complex nature, influenced by tumor burden, liver… Continue reading →

“Thank you for removing those polyps during the colonoscopy today. If I change my diet, can I reduce the risk of developing more polyps or colon cancer in the future?” This is one of the most commonly posed questions by our patients, after being in… Continue reading →

Colorectal cancer (CRC) incidence and mortality in the United States have changed strikingly in recent decades. Overall, CRC incidence decreased by >30% from 1975 (59.5 per 100,000) to 2013 (37.9 per 100,000).1 CRC mortality similarly declined from 28.1 per 100,000 in 1975 to 14.5 per 100,000 in 2013—nearly a 50% decrease.1 Screen-eligible populations, particularly those over age 65, have experienced the largest declines in incidence and mortality.2,3 Continue reading →

Bile acid synthesis and composition is tightly controlled through the mechanisms involved in the enterohepatic circulation, also referred to as the gut–microbiota–liver axis (Figure 1A). Disruptions in the balance—be it through genetic, metabol… Continue reading →

The epidemiology of Helicobacter pylori infection has changed with improvements in sanitation and methods of eradication. We performed a systematic review and meta-analysis to evaluate changes in the global prevalence of H pylori infection. Continue reading →

Tumor necrosis factor (TNF) an inflammatory cytokine expressed by human fetal liver cells (HFLCs) following infection with cell culture-derived hepatitis C virus. TNF has been reported to increase entry of HCV pseudoparticles into hepatoma cells and in… Continue reading →

In nematodes, the intestine senses and integrates early-life dietary cues that lead to lifelong epigenetic adaptations to a perceived nutritional environment—it is not clear whether this process occurs in mammals. We aimed to establish a mouse model … Continue reading →

Depletion of interstitial cells of Cajal (ICCs) is common in diabetic gastroparesis. However, in approximately 20% of patients with diabetes, gastric emptying (GE) is accelerated. GE is also faster in obese individuals, and is associated with increased… Continue reading →