Monthly Archives: April 2017
Intratumoural Epigenetic Heterogeneity in Early Invasive Colorectal Cancer: A Prognostic Imprint?
We read with interest the manuscript from Martínez-Cardús et al,1 which defines methylation heterogeneity, both interpatient and intratumoral, using multiregional sampling in colorectal cancer (CRC). The authors show that samples will cluster accord… Continue reading
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Exam 2: Timing Affects Measurement of Portal Pressure Gradient After Placement of Transjugular Intrahepatic Portosystemic Shunts in Patients With Portal Hypertension
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Tapering of Immunosuppression and Sustained Treatment With Nivolumab in a Liver Transplant Recipient
Recurrence rates in hepatocellular carcinoma (HCC) patients selected for liver transplantation have drastically improved after the Milan criteria were established. However, about 10% of these patients still experience a recurrence within 5 years.1 For … Continue reading
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Chemoprevention of Barrett’s Esophagus With Nonsteroidal Anti-Inflammatory Drugs
Thrift AP, Anderson LA, Murray LJ, et al. nonsteroidal anti-inflammatory drug use is not associated with reduced risk of Barrett’s esophagus. Am J Gastroenterol 2016;111:1528-1535. Continue reading
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Transarterial Chemoembolization vs Yttrium-90 Transarterial Radioembolization
We read with interest the results of the PREMIERE trial by Salem et al,1 a randomized controlled trial comparing transarterial chemoembolization (TACE) and yttrium-90 (Y90) transarterial radioembolization in patients with hepatocellular carcinoma (HCC… Continue reading
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Ustekinumab for Crohn’s Disease
“If you come to a fork in the road, take it.”—Yogi Berra Continue reading
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A Unique Cause of Persistent Diarrhea
Question: A 60-year-old man with a 5-year history of intermittent diarrhea had been experiencing approximately 5 episodes a day when he visited our hospital. The diarrhea was watery, and he had no abdominal pain, but slight edema was noted in his lower… Continue reading
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Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside
Alcoholic fatty liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are 2 of the most common and important liver diseases facing physicians in the 21st century. Because they are so histologically similar, there is a common belief that ALD … Continue reading
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The Case for a Multitarget Stool DNA Test: A Closer Look at the Cost Effectiveness Model
The recent analysis by Ladabaum and Mannalithara concluded that multitarget stool DNA test (MT-sDNA) was less cost-effective than other colorectal cancer (CRC) screening strategies.1 We commend the authors for tackling this important topic, but questio… Continue reading
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An Unusual Appearance of the Colon Wall
Question: A 64-year-old man presented for his first average-risk screening colonoscopy. The patient reported occasional abdominal cramps, but was otherwise without any symptoms or medical problems. Physical examination was unremarkable, and review of … Continue reading
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