Monthly Archives: April 2017
Deep Beneath the Skin: An Unusual Causa of Melena
Question: A 76-year-old man presented to the emergency department complaining of exertional dyspnea in the previous 3 weeks and an episode of presyncope that day. He denied orthopnea, paroxysmal nocturnal dyspnea, and precordial pain. On further ques… Continue reading
Exam 1: Doppler Endoscopic Probe Monitoring of Blood Flow Improves Risk Stratification and Outcomes of Patients With Severe Nonvariceal Upper Gastrointestinal Hemorrhage
Rifaximin in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome
We read with interest the article by Lembo et al1 evaluating the safety and efficacy of repeat treatment with rifaximin in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). The authors found that repeat rifaximin treatment was effic… Continue reading
Exam 3: Role of Transient Elastography in Chronic Liver Diseases
Reply
The 2008 Journal of the National Cancer Institute guidelines recommend time to progression (TTP) in the randomized phase II setting for intermediate hepatocellular carcinoma (HCC).1 PREMIERE complied with the recommendation and was initiated in 2009. I… Continue reading
Reply
The comments by Itzkowitz and Ahlquist made us recall George Box’s saying that “all models are wrong but some are useful.” We acknowledge that our model is a simplification of reality, and we agree that its assumptions must be appreciated, but we… Continue reading
RE: Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma
We would like to congratulate the authors for the first randomized phase 2 study comparing the effects of conventional transarterial chemoembolization (cTACE) and Y90 radioembolization (Y90) in patients with hepatocellular carcinoma (HCC).1 This study … Continue reading