Daily Archives: May 4, 2017
Ruxolitinib for the Treatment of Portal Hypertension in a Patient With Primary Myelofibrosis
Primary myelofibrosis is a form of myeloproliferative neoplasm characterized by stem-cell derived clonal proliferation, resulting in bone marrow fibrosis, splenomegaly and extramedullary haematopoiesis, with portal hypertension (PHT) occuring in 10%–… Continue reading
Unusual Case of Abdominal Pain: Finding the Missing Part
Question: A 24-year-old man presented to us with a 6-month history of epigastric pain aggravated by meals. Additional history revealed no radiation of the pain or any associated symptoms of loss of appetite, loss of weight, use of nonsteroidal antiinflammatory drugs before the onset of pain, recent trauma, or surgery. General physical and systemic examinations were unremarkable. Laboratory testing showed normal serum amylase and lipase levels. His blood sugars and glycated hemoglobin A1C (HbA1C) were also within normal limits (fasting blood sugar, 96 mg/dL [normal, <100], postprandial blood sugar, 116 mg/dL [normal, <200), HbA1c, 5.4 [normal range, 4.2–6.2]). Continue reading
An Unusual Case of Iron Deficiency and Cardiac Murmur
Question: A 22-year-old man presented with 1-week history of left-sided chest pain radiating to the back and fatigue. Past medical history was significant for truncus arteriosus with late valvular repair complicated by secondary pulmonary hypertension…. Continue reading
Isthmus Progenitors, Not Chief Cells, Are the Likely Origin of Metaplasia in eR1-CreERT; LSL-KrasG12D Mice
We read with great interest the recent publication by Matsuo et al1 and the accompanying editorial by Goldenring and Mills.2 We agree with the authors that the Runx1 enhancer element, eR1, marks among other cell types a stem cell population within the… Continue reading
Rare Cause for a Colonic Ulcerated Stricture
Question: A 70-year-old male patient, with a history of Madelung disease, ischemic heart disease, hypertension, diabetes mellitus and dyslipidemia, was diagnosed with a stage IV adenocarcinoma of the cephalic portion of the pancreas. Continue reading
Peripancreatic Mass of Unknown Origin
Question: A 66-year-old man with past medical history of asthma, hypertension, type 2 diabetes mellitus, chronic kidney disease, hypoganadism, and gynecomastia presented with acute abdominal pain that led to an emergency room computed tomography (CT) s… Continue reading
An Intriguing Cause of Dysphagia
Question: A 64-year-old man presented with intermittent episodes of dysphagia to solids, which has been nonprogressive over the past 3 months. He denied any history of chest pain, vomiting, reflux symptoms, loss of appetite, or loss of weight. He is … Continue reading
Exam 2: Menopausal Hormone Therapy is Associated With Increased Risk of Fecal Incontinence in Women After Menopause
A Young Man With Abdominal Pain, Weight Loss and Jaundice
Question: A 20-year-old, previously healthy college student developed acute abdominal pain and vomiting. Symptoms started about 2 weeks before presentation. His pain was epigastric and nonradiating and the emesis was bilious and nonbloody. He reported … Continue reading