Daily Archives: May 4, 2017
Proton Pump Inhibitors and the Possible Development of Hepatic Encephalopathy in Cirrhotic Patients: True Association or Residual Confounding?
In their recent study, Tsai et al1 evaluated a possible association between proton pump inhibitor (PPI) use and the development of hepatic encephalopathy (HE) in patients with cirrhosis. This is the second report of which we are aware that has examine… Continue reading
Exam 3: Micro-Coordination of Pacemaker Potentials in the Intestine of the Mouse
Pelvic Physiotherapy in Children With Functional Constipation: Promising But More Research Needed
We congratulate van Engelenburg-van Lonkhuyzen et al1 on their study on the effectiveness of pelvic physiotherapy in children with functional constipation. This randomized, controlled trial showed that pelvic physiotherapy was more effective than stan… Continue reading
Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis: a Systematic Review and Meta-Analysis
Liver cirrhosis is complicated by bleeding from portal hypertension but also by portal vein thrombosis (PVT). PVT occurs in about 20%–50% of patients with cirrhosis, and is a warning sign for poor outcome. It is a challenge to treat patients with cir… Continue reading
Reply
We appreciate the interest of Summeren et al in our study and their careful and thorough discussion of the potential caveats and context required to interpret our findings. Continue reading
Extracellular Vesicles in Bile as Markers of Malignant Biliary Stenoses
Algorithms for diagnosis of malignant common bile duct (CBD) stenoses are complex and lack accuracy. Malignant tumors secrete large numbers of extracellular vesicles (EVs) into surrounding fluids; EVs might therefore serve as biomarkers for diagnosis. … Continue reading
A Multifocal Abdominal Mass in a Renal Transplant Recipient
Question: A 69-year-old renal transplant patient was hospitalized because of persistent dyspepsia, anorexia with progressive weight loss, and intermittent loose stools. She received a cadaveric kidney 18 months ago complicated by an acute antibody-medi… Continue reading
Higher Incidence of Clostridium difficile Infection Among Individuals With Inflammatory Bowel Disease
Studies of Clostridium difficile infections (CDIs) among individuals with inflammatory bowel disease (IBD) have used data from single centers or CDI administrative data codes of limited diagnostic accuracy. We determined the incidence, risk factors, an… Continue reading
Re: Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease
We read with great interest the original article by Brant et al.1 The discovery of African American (AA)-specific loci and loci that are shared between ethnic groups highlight the importance of studying inflammatory bowel disease in other populations … Continue reading