Monthly Archives: May 2017

An Unusual Case of Iron Deficiency and Cardiac Murmur

Question: A 22-year-old man presented with 1-week history of left-sided chest pain radiating to the back and fatigue. Past medical history was significant for truncus arteriosus with late valvular repair complicated by secondary pulmonary hypertension…. Continue reading

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Isthmus Progenitors, Not Chief Cells, Are the Likely Origin of Metaplasia in eR1-CreERT; LSL-KrasG12D Mice

We read with great interest the recent publication by Matsuo et al1 and the accompanying editorial by Goldenring and Mills.2 We agree with the authors that the Runx1 enhancer element, eR1, marks among other cell types a stem cell population within the… Continue reading

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Rare Cause for a Colonic Ulcerated Stricture

Question: A 70-year-old male patient, with a history of Madelung disease, ischemic heart disease, hypertension, diabetes mellitus and dyslipidemia, was diagnosed with a stage IV adenocarcinoma of the cephalic portion of the pancreas. Continue reading

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Peripancreatic Mass of Unknown Origin

Question: A 66-year-old man with past medical history of asthma, hypertension, type 2 diabetes mellitus, chronic kidney disease, hypoganadism, and gynecomastia presented with acute abdominal pain that led to an emergency room computed tomography (CT) s… Continue reading

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An Intriguing Cause of Dysphagia

Question: A 64-year-old man presented with intermittent episodes of dysphagia to solids, which has been nonprogressive over the past 3 months. He denied any history of chest pain, vomiting, reflux symptoms, loss of appetite, or loss of weight. He is … Continue reading

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Exam 2: Menopausal Hormone Therapy is Associated With Increased Risk of Fecal Incontinence in Women After Menopause

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A Young Man With Abdominal Pain, Weight Loss and Jaundice

Question: A 20-year-old, previously healthy college student developed acute abdominal pain and vomiting. Symptoms started about 2 weeks before presentation. His pain was epigastric and nonradiating and the emesis was bilious and nonbloody. He reported … Continue reading

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Exam 1: Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis

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Proton Pump Inhibitors and the Possible Development of Hepatic Encephalopathy in Cirrhotic Patients: True Association or Residual Confounding?

In their recent study, Tsai et al1 evaluated a possible association between proton pump inhibitor (PPI) use and the development of hepatic encephalopathy (HE) in patients with cirrhosis. This is the second report of which we are aware that has examine… Continue reading

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Exam 3: Micro-Coordination of Pacemaker Potentials in the Intestine of the Mouse

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