Monthly Archives: June 2017

We appreciate the comments by Hayakawa and Wang on our original study.1 They raise important issues concerning the location of stem cells as well as the origin of metaplasia in the stomach. Continue reading →

We thank Dr Khan and Dr Assaraf for their responses to our publication.1 Continue reading →

Coordinated contractions of the stomach are integrated motor responses classically described as consisting of “neurogenic” and “myogenic” components. In the last 2 decades, dissection of the myogenic elements using genetic, molecular, morpholog… Continue reading →

Marietta EV, Geno DM, Smyrk TC, et al. Presence of intraepithelial food antigen in patients with active eosinophilic oesophagitis. Aliment Pharmacol Ther 2017;45:427–433. Continue reading →

Vermeire S, Schreiber S, Petryka R, et al. Clinical remission in patients with moderate-to-severe Crohn’s disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-controlled trial. Lancet 2017;389:… Continue reading →

Ligand binding to inhibitory receptors on immune cells, such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), downregulates the T-cell–mediated immune response (called immune checkpoints). Antibodies that blo… Continue reading →

Ligand binding to inhibitory receptors on immune cells, such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), down-regulates the T-cell–mediated immune response (called immune checkpoints). Antibodies that bl… Continue reading →