Monthly Archives: June 2017
The Future of Endoscopic Retrograde Cholangiopancreatography
Since its introduction nearly 50 years ago, there has been considerable evolution in the practice and performance of ERCP. On the one hand, therapeutic ERCP has supplanted surgical and percutaneous radiologic procedures to emerge as the dominant method… Continue reading
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Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor
Intestinal fibrosis resulting in (sub)obstruction is a common complication of Crohn’s disease (CD). Rho kinases (ROCKs) play multiple roles in TGFβ-induced myofibroblast activation that could be therapeutic targets. Because systemic ROCK inhibition … Continue reading
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Risk of Hepatocellular Cancer in HCV Patients Treated With Direct Acting Antiviral Agents
The risk of hepatocellular cancer (HCC) after sustained virological response (SVR) with direct acting antivirals (DAA) is unclear. Our aim was to examine the risk and determinants of HCC in patients cured with DAA. Continue reading
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Risk of Hepatocellular Cancer in HCV Patients Treated with Direct Acting Antiviral Agents
The risk of hepatocellular cancer (HCC) after sustained virological response (SVR) with direct acting antivirals (DAA) is unclear. Our aim was to examine the risk and determinants of HCC in patients cured with DAA. Continue reading
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Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor
Intestinal fibrosis resulting in (sub)obstruction is a common complication of Crohn’s disease (CD). Rho kinases (ROCKs) play multiple roles in TGFβ1-induced myofibroblast activation that could be therapeutic targets. Because systemic ROCK inhibition… Continue reading
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Pharmacological Rescue of Ductal CFTR Rescue Pancreatic and Salivary glands Acinar Cells and Tissue Function in Mouse Models of Autoimmune diseases
Sjögren’s syndrome and autoimmune pancreatitis (AIP) are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. NOD/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren’s syndrome and chronic … Continue reading
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Pharmacological Rescue of Ductal CFTR Rescue Pancreatic and Salivary Glands Acinar Cells and Tissue Function in Mouse Models of Autoimmune Diseases
Sjögren’s syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren’s syndrome and… Continue reading
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Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial
Dietary restriction of fermentable carbohydrates (a low FODMAP diet) has been reported to reduce symptoms in some patients with irritable bowel syndrome (IBS). We performed a randomized, placebo-controlled study to determine its effects on symptoms and… Continue reading
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Association Between Natural Killer Cell Activity and Colorectal Cancer in High-risk Subjects Undergoing Colonoscopy
Low activity of natural killer (NK) cells has been associated with increased risk of cancer and has been reported in patients with colorectal cancer (CRC). Activity of NK cells can be measured in a small volume of whole blood by a commercially availabl… Continue reading
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