Daily Archives: July 3, 2017

First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease

Posted on July 3, 2017 by Gastroenterology Journal

By catalyzing generation of hydrogen peroxide (H202) in enterocytes, DUOX2 participates in innate defense against intestinal microbes.1,2 One monoallelic exonic variant of DUOX2 was recently found in 15 out of 19 Crohn disease-affected patients in a la… Continue reading →

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