Daily Archives: July 28, 2017

Sandborn W, Su C, Sands BE, et al. Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med 2017;376:2017;1723-1736. Continue reading →

In this issue of Gastroenterology Klatte et al1 report an association of chronic kidney disease with proton pump inhibitor (PPI) use. This paper adds to the large number of observational studies suggesting an association of PPIs with different conditi… Continue reading →

The era of direct-acting antivirals (DAAs) has transformed the treatment landscape for chronic hepatitis C virus (HCV) infection. Primarily this is due to the approval of multiple DAAs that are highly efficacious with improved safety profiles that beca… Continue reading →

Ten Hove JR, et al. Clinical implications of low grade dysplasia found during inflammatory bowel disease surveillance: a retrospective study comparing chromoendoscopy and white-light endoscopy. Endoscopy 2017;49:161-168. Continue reading →

The larger the polyp, the greater the cancer risk. Among polyps >20 mm in size, the risk may exceed 10%.1 Although some polyps portray overt signs of cancer through their pit pattern or a depressed morphology,2,3 others are covert without such worrisome characteristics. Cancers with minimal invasion into the submucosa can be removed completely by endoscopic resection and, in the absence of lymphovascular invasion or poor differentiation, for almost all complete resection equates to cure.4 To prove a healthy margin and confirm complete resection, the polyp has to be removed in 1 piece (en bloc). Continue reading →

Training fellows to perform endoscopy is challenging. Most trainers genuinely desire to be good teachers, but competing demands can be difficult to navigate. As we consider the hypothetical example below, think about what you might do differently. Continue reading →

Eosinophilic esophagitis (EoE) is an emerging disease that is distinguished from gastroesophageal reflux disease (GERD) by the expression of a unique esophageal transcriptome and the interplay of early life environmental factors with distinct genetic s… Continue reading →

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world, affecting an estimated 25% of the global adult population.1 Liver-related morbidity and mortality attributed to NAFLD are substantial, and fibros… Continue reading →

In this issue of Gastroenterology, Schwarz et al1 report on the “Impact of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis and Insulin Kinetics in Children with Obesity.” There are 3 recent developments important to the context and … Continue reading →

Colorectal cancer (CRC) screening using quantitative fecal immunochemical tests (FITs) is rapidly gaining ground worldwide. FITs are invariably used in a dichotomous manner using pre-specified cut-off values. To optimize FIT-based screening programs, w… Continue reading →