Daily Archives: July 28, 2017

Esophageal squamous cell carcinoma (ESCC) is a common malignancy without effective therapy. The exomes of more than 600 ESCCs have been sequenced in the last 4 years, and numerous key aberrations have been identified1-4. Recently, researchers reported … Continue reading →

Gastroparesis is a complication of diabetes with few treatment options. Relamorelin (also called RM-131) is a selective, prokinetic agonist of ghrelin. We aimed to evaluate efficacy of relamorelin on symptoms and gastric emptying (GE) in a 12-week, pha… Continue reading →

The larger the polyp, the greater the cancer risk. Among polyps >20 mm in size, the risk may exceed 10%.1 Although some polyps portray overt signs of cancer through their pit pattern or a depressed morphology,2,3 others are covert without such worrisome characteristics. Cancers with minimal invasion into the submucosa can be removed completely by endoscopic resection and, in the absence of lymphovascular invasion or poor differentiation, for almost all complete resection equates to cure.4 To prove a healthy margin and confirm complete resection, the polyp has to be removed in 1 piece (en bloc). Continue reading →

In this issue of Gastroenterology Klatte et al1 report an association of chronic kidney disease with proton pump inhibitor (PPI) use. This paper adds to the large number of observational studies suggesting an association of PPIs with different conditi… Continue reading →

In this issue of Gastroenterology, Schwarz et al1 report on the “Impact of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis and Insulin Kinetics in Children with Obesity.” There are 3 recent developments important to the context and … Continue reading →

Sandborn W, Su C, Sands BE, et al. Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med 2017;376:2017;1723-1736. Continue reading →

Ten Hove JR, et al. Clinical implications of low grade dysplasia found during inflammatory bowel disease surveillance: a retrospective study comparing chromoendoscopy and white-light endoscopy. Endoscopy 2017;49:161-168. Continue reading →

The era of direct-acting antivirals (DAAs) has transformed the treatment landscape for chronic hepatitis C virus (HCV) infection. Primarily this is due to the approval of multiple DAAs that are highly efficacious with improved safety profiles that beca… Continue reading →

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease worldwide and is an increasing cause of liver-related morbidity and mortality. Nonalcoholic steatohepatitis (NASH), the progressive histological subtype of the… Continue reading →

Training fellows to perform endoscopy is challenging. Most trainers genuinely desire to be good teachers, but competing demands can be difficult to navigate. As we consider the hypothetical example below, think about what you might do differently. Continue reading →