Monthly Archives: July 2017
Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma
Induction of non-apoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We investigated necroptosis-based therapies in mouse models of pancreatic ductal adenocarcinoma cancer (PDAC). Continue reading
Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma
Induction of non-apoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We investigated necroptosis-based therapies in mouse models of pancreatic ductal adenocarcinoma cancer (PDAC). Continue reading
Tofacitinib Is the Right OCTAVE for Ulcerative Colitis
Sandborn W, Su C, Sands BE, et al. Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med 2017;376:2017;1723-1736. Continue reading
Proton Pump Inhibitors and Chronic Kidney Disease: Causation or Another False Alarm?
In this issue of Gastroenterology Klatte et al1 report an association of chronic kidney disease with proton pump inhibitor (PPI) use. This paper adds to the large number of observational studies suggesting an association of PPIs with different conditi… Continue reading
Public–Private Partnership: Targeting Real-World Data for Hepatitis C Direct-Acting Antivirals
The era of direct-acting antivirals (DAAs) has transformed the treatment landscape for chronic hepatitis C virus (HCV) infection. Primarily this is due to the approval of multiple DAAs that are highly efficacious with improved safety profiles that beca… Continue reading
Chromoendoscopy versus White Light Endoscopy: Does it Matter?
Ten Hove JR, et al. Clinical implications of low grade dysplasia found during inflammatory bowel disease surveillance: a retrospective study comparing chromoendoscopy and white-light endoscopy. Endoscopy 2017;49:161-168. Continue reading
Carving Out a Place for Endoscopic Submucosal Dissection
The larger the polyp, the greater the cancer risk. Among polyps >20 mm in size, the risk may exceed 10%.1 Although some polyps portray overt signs of cancer through their pit pattern or a depressed morphology,2,3 others are covert without such worrisome characteristics. Cancers with minimal invasion into the submucosa can be removed completely by endoscopic resection and, in the absence of lymphovascular invasion or poor differentiation, for almost all complete resection equates to cure.4 To prove a healthy margin and confirm complete resection, the polyp has to be removed in 1 piece (en bloc). Continue reading
How to Give Feedback During Endoscopy Training
Training fellows to perform endoscopy is challenging. Most trainers genuinely desire to be good teachers, but competing demands can be difficult to navigate. As we consider the hypothetical example below, think about what you might do differently. Continue reading
Pathophysiology of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is an emerging disease that is distinguished from gastroesophageal reflux disease (GERD) by the expression of a unique esophageal transcriptome and the interplay of early life environmental factors with distinct genetic s… Continue reading
Baseline Parameters in Clinical Trials for Nonalcoholic Steatohepatitis: Recommendations From the Liver Forum
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world, affecting an estimated 25% of the global adult population.1 Liver-related morbidity and mortality attributed to NAFLD are substantial, and fibros… Continue reading