Monthly Archives: July 2017
MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms
Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these… Continue reading
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MET Signaling Mediates Intestinal Crypt Villus Development, Regeneration, and Adenoma Formation and is Promoted by Stem Cell CD44 Isoforms
Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor receptor (EGFR) signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of thes… Continue reading
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Detection, Diagnosis and Resection of Sessile Serrated Adenomas/Polyps
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The evolving genomic landscape of Barrett’s esophagus and esophageal adenocarcinoma
We have recently gained unprecedented insight into genetic factors that determine risk for Barrett’s esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutatio… Continue reading
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Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury
Adult liver stem cells are usually maintained in a quiescent/slow cycling state. However, a proliferative population, marked by leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), was recently identified as an important liver stem cell … Continue reading
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Diffuse small intestine erosions and ulcers in an immunocompromised host
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Elderly lady with upper abdominal pain and 60 pounds weight loss
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A Rare but Curable Cause of Iron Deficiency Anemia
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An unusual cause of a solid-cystic pancreatic lesion
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A surprising granulomatous cheilitis
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